Persianinov L S, Massal'skaia L M
Biull Eksp Biol Med. 1975 Nov;80(11):87-90.
It was shown that at various stages of the first mitotic cycles the developing ova of Strongylocentrotus intermedius displayed a different sensitivity to toxic concentrations of prostaglandin F2alpha and to cyclic 3',5'-adenosinmonophosphate (cAMP). The differences in the sensitivity to each of these substances were regular and similar in character and depended on the time lapse after the completion of division next in turn. There were revealed two periods of increased sensitivity of the ova--the first one--during the 20th minute after the completion of each division--to both substances, and the second one--during the 40th minute--to cAMP, and during the 50th minute--to prostaglandin F2alpha.
结果表明，在中间球海胆发育中的卵子第一次有丝分裂周期的各个阶段，其对前列腺素F2α的毒性浓度以及对环磷酸腺苷（cAMP）表现出不同的敏感性。对每种物质敏感性的差异具有规律性且性质相似，并取决于上一次分裂完成后的时间间隔。发现卵子存在两个敏感性增加的时期——第一个时期——在每次分裂完成后的第20分钟——对两种物质均敏感，第二个时期——在第40分钟——对cAMP敏感，在第50分钟——对前列腺素F2α敏感。
