Schiavon R, Turazzini M, De Fanti E, Battaglia P, Targa L, Del Colle R, Fasolin A, Silvestri M, Biasioli S, Guidi G
Laboratory Medicine, 'Mater Salutis' Hospital, Legnago, Italy.
Acta Neurol Scand. 2007 Jul;116(1):26-30. doi: 10.1111/j.1600-0404.2006.00765.x.
Paraoxonase-1 (PON1) is an esterase with antioxidant properties. Low PON1 enzyme activity or specific allelic polymorphisms seem to be associated with the risk of developing coronary artery disease or acute ischemic stroke (AIS). Our objective was to determine the distribution of both PON1 enzyme activity and its genotype in a group of patients with AIS.
PON1 activity and the relative Q192R and L55M polymorphisms in the PON1 gene were assessed on 126 survivors of a first AIS and in 92 healthy subjects.
The genotype distribution for PON1 Q192R and L55M polymorphisms was similar in AIS patients and healthy subjects, but patients carrying the QRLL or RRLL genotype combination had lower PON1 enzyme activity compared with healthy subjects with the same genotype.
We postulate that lower than expected PON1 enzyme activity within specific genotypes might explain the reported association between R and L alleles and the risk of developing AIS.
对氧磷酶-1（PON1）是一种具有抗氧化特性的酯酶。低PON1酶活性或特定的等位基因多态性似乎与冠状动脉疾病或急性缺血性卒中（AIS）的发病风险相关。我们的目的是确定一组AIS患者中PON1酶活性及其基因型的分布情况。
对126例首次发生AIS的幸存者和92例健康受试者评估PON1活性以及PON1基因中相对的Q192R和L55M多态性。
AIS患者和健康受试者中PON1 Q192R和L55M多态性的基因型分布相似，但与具有相同基因型的健康受试者相比，携带QRLL或RRLL基因型组合的患者PON1酶活性较低。
我们推测特定基因型内低于预期的PON1酶活性可能解释了所报道的R和L等位基因与发生AIS风险之间的关联。
