Sheen-Chen S-M, Eng H-L
Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung, College of Medicine, Chang Gung University, Taiwan.
Eur J Cancer Care (Engl). 2007 Jul;16(4):331-2. doi: 10.1111/j.1365-2354.2006.00750.x.
The development of malignant lymphoma following breast cancer has not been described before. Here we report the development of malignant lymphoma at the ipsilateral chest wall subsequent to the surgical treatment of breast cancer. A 48-year-old woman underwent modified radical mastectomy due to breast carcinoma. Tamoxifen (10 mg twice daily) was given 3 years after the operation and continued for about 3 years. The patient was well until she recently (17 years after the initial operation) noted a small lump at her left anterior chest wall near the axilla. The local tumour mass was initially assumed to be a local recurrent lesion of breast cancer. Excisional biopsy was performed and eventually was histologically diagnosed to be malignant lymphoma. In view of the therapeutic implication, the development of second malignancy should not be mistaken as a progression of the known primary malignancy. Only with the awareness of such entity, can the prompt diagnosis and proper treatment be achieved.
乳腺癌后发生恶性淋巴瘤此前尚未见报道。在此我们报告1例乳腺癌手术治疗后同侧胸壁发生恶性淋巴瘤的病例。1名48岁女性因乳腺癌接受了改良根治性乳房切除术。术后3年给予他莫昔芬（每日2次，每次10 mg），持续约3年。该患者情况良好，直到最近（初次手术后17年）她注意到左前胸壁靠近腋窝处有一个小肿块。局部肿瘤最初被认为是乳腺癌的局部复发病变。进行了切除活检，最终经组织学诊断为恶性淋巴瘤。鉴于其治疗意义，不应将第二原发恶性肿瘤的发生误诊为已知原发恶性肿瘤的进展。只有认识到这种情况，才能实现早期诊断和恰当治疗。
