Cardiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 186-8582, Japan.
Circ J. 2007;71 Suppl A:A45-9. doi: 10.1253/circj.71.a45.
Cardiac stem cell based therapy is a promising therapy for patients with severe heart failure. Many types of stem cells, such as embryonic stem cells, myoblasts, marrow-derived mesenchymal stem cells, circulating endothelial progenitor cells, and cardiac precursor cells etc, are known as cellular sources for cardiac stem cell therapy. Both in the clinical and experimental setting, stem cells are reported, and supposed, to cause some arrhythmogenic adverse effects. In order to overcome these serious adverse effects, it is necessary to know the electrophysiological properties of stem cell-derived cardiomyocytes, and have a profound insight into the mechanisms of arrhythmia to know whether such arrhythmogenic properties of the cells can cause serious arrhythmia in situ. In the present study, recent publications that focus on the electrophysiological aspect of stem cell based therapy are reviewed and, furthermore, a new perspective on cardiac stem cell therapy of arrhythmias is given.
基于心脏干细胞的治疗是一种有前途的治疗严重心力衰竭患者的方法。许多类型的干细胞，如胚胎干细胞、成肌细胞、骨髓间充质干细胞、循环内皮祖细胞和心脏前体细胞等，被认为是心脏干细胞治疗的细胞来源。在临床和实验环境中，据报道和假设干细胞会引起一些致心律失常的不良反应。为了克服这些严重的不良反应，有必要了解干细胞衍生的心肌细胞的电生理特性，并深入了解心律失常的机制，以了解这些细胞的致心律失常特性是否会在体内引起严重的心律失常。在本研究中，对目前关注基于干细胞治疗的电生理学方面的最新出版物进行了综述，并对心律失常的心脏干细胞治疗提出了新的观点。
