Nabeno Yuka, Fukuchi Yoshiko, Matsutani Yasuko, Naito Michitaka
Division of Nutrition and Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan.
J Atheroscler Thromb. 2007 Jun;14(3):142-50. doi: 10.5551/jat.14.142.
To analyze the influence of menopause and age on postprandial lipoprotein responses in healthy adult women.
Twenty-seven healthy young and middle-aged pre- and postmenopausal female volunteers aged 21-53 y were enrolled. They ingested OFTT cream(Jomo, Takasaki, Japan). Fasting and postprandial blood samples were obtained for up to 6 h, and serum concentrations of lipoproteins were analyzed.
In the postprandial phase, serum triglycerides(TG), remnant-like particle(RLP)-TG(RLP-TG), RLP-cholesterol(RLP-C), and TG-rich lipoprotein-TG(TRL-TG)concentrations in all groups peaked after 2 h. After 4 h, the TG, RLP-C, RLP-TG and TRL-TG concentrations in the young women returned to the fasting concentrations. However, at 6 h, these parameters in the pre- and postmenopausal women had barely returned to the fasting concentrations.
The present results suggest that:(1)the magnitude of postprandial TG concentrations is dependent on age, but not on menopause;(2)clearance of remnant lipoproteins is delayed with age in pre- and postmenopausal women compared to young women, and(3)menopause is associated with an increase of RLP-C, but may not influence LDL particle size.
分析绝经和年龄对健康成年女性餐后脂蛋白反应的影响。
招募了27名年龄在21 - 53岁之间的健康中青年绝经前和绝经后女性志愿者。她们摄入了OFTT乳剂（日本高崎市Jomo公司）。采集空腹和餐后长达6小时的血样，并分析血清脂蛋白浓度。
在餐后阶段，所有组的血清甘油三酯（TG）、残粒样颗粒（RLP）-TG（RLP-TG）、RLP-胆固醇（RLP-C）和富含TG的脂蛋白-TG（TRL-TG）浓度在2小时后达到峰值。4小时后，年轻女性的TG、RLP-C、RLP-TG和TRL-TG浓度恢复到空腹浓度。然而，在6小时时，绝经前和绝经后女性的这些参数几乎没有恢复到空腹浓度。
目前的结果表明：（1）餐后TG浓度的幅度取决于年龄，而非绝经；（2）与年轻女性相比，绝经前和绝经后女性残粒脂蛋白的清除随年龄延迟，且（3）绝经与RLP-C增加有关，但可能不影响低密度脂蛋白颗粒大小。
