Park Tae-Gon, Hong Hae-Ryen, Lee Jiyoung, Kang Hyun-Sik
Department of Physical Education, Pusan National University, Pusan, Republic of Korea.
Ann Nutr Metab. 2007;51(3):197-203. doi: 10.1159/000104137. Epub 2007 Jun 18.
BACKGROUND/AIMS: Little is known about whether lifestyle plus exercise intervention improves obesity, metabolic syndrome markers, and circulating adiponectin concentrations in obese girls. The goal of this study was to investigate the effects of a 12-week lifestyle plus exercise intervention on adiponectin and metabolic syndrome markers in Korean obese adolescents.
A total of 44 obese adolescent girls (13-15 years old), who were recruited from a local middle school via a flyer or a school newsletter, were randomized to a lifestyle plus exercise intervention group (LIFE+EX, n = 22) or control (CON, n = 22). The LIFE+EX group participated in 12 weeks of lifestyle plus exercise intervention, while the CON group maintained their lifestyle as usual. Body composition, metabolic syndrome markers, and adiponectin were measured prior to and after the intervention program.
Following the 12-week lifestyle plus exercise intervention, group analyses showed significant time x group interactions in changed scores in several of the metabolic syndrome markers such that the LIFE+EX group had significantly greater improvements in body composition including body weight, body mass index, percent body fat, waist circumference, and waist-to-hip ratio than the CON group. Similarly, the LIFE+EX group had significantly greater reductions in SBP, TC, LDLC, TG, TC/HDLC, glucose, insulin, HOMA-IR, CRP, and leptin than the CON group, while there were no significant time x group or time or group differences in DBP, HDLC, HbA1c, and adiponectin.
The current findings suggest that lifestyle plus exercise intervention may be an effective means to improve several variables in the health hazards of obesity in Korean adolescent girls, with no change in circulating adiponectin.
背景/目的：关于生活方式加运动干预是否能改善肥胖女孩的肥胖状况、代谢综合征指标和循环脂联素浓度，目前所知甚少。本研究的目的是调查为期12周的生活方式加运动干预对韩国肥胖青少年脂联素和代谢综合征指标的影响。
通过传单或学校通讯从当地一所中学招募了44名肥胖青春期女孩（13 - 15岁），随机分为生活方式加运动干预组（LIFE+EX，n = 22）或对照组（CON，n = 22）。LIFE+EX组参加为期12周的生活方式加运动干预，而CON组保持其通常的生活方式。在干预项目前后测量身体成分、代谢综合征指标和脂联素。
经过12周的生活方式加运动干预后，组间分析显示在几个代谢综合征指标的变化分数上存在显著的时间×组间交互作用，即LIFE+EX组在身体成分方面包括体重、体重指数、体脂百分比、腰围和腰臀比的改善显著大于CON组。同样，LIFE+EX组在收缩压、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、总胆固醇/高密度脂蛋白胆固醇、血糖、胰岛素、胰岛素抵抗指数、C反应蛋白和瘦素方面的降低显著大于CON组，而在舒张压、高密度脂蛋白胆固醇、糖化血红蛋白和脂联素方面不存在显著的时间×组间或时间或组间差异。
目前的研究结果表明，生活方式加运动干预可能是改善韩国青春期女孩肥胖健康危害中几个变量的有效手段，而循环脂联素无变化。
