Dragoumani Konstantina, Troumbis Andreas, Bacopoulou Flora, Chrousos George
Department of Food Science and Nutrition, University of the Aegean, 81400 Lemnos, Greece.
Department of Environmental Studies, University of the Aegean, 81100 Mytilene, Greece.
J Pers Med. 2023 Aug 28;13(9):1322. doi: 10.3390/jpm13091322.
There have been numerous attempts to establish a correlation between obesity and stress, inflammatory, and dysmetabolism biomarkers in children and adolescents. Here, we performed a meta-analysis of existing studies to shed light on the elusive correlations of childhood and adolescent obesity with physiological indicators of stress, inflammation, and metabolism before and after lifestyle interventions. Observational studies, meta-analyses, narrative and systematic reviews were excluded. From a total of 53 articles, 11 were selected according to specific criteria. The biomarkers examined were circulating glucose, insulin, HDL, LDL, triglycerides, adiponectin, leptin, CRP, TNF-alpha, interleukin (IL)-6, systolic and diastolic blood pressure, and HOMA-IR. All analyses were performed using IBM SPSS Statistics Version 28.0.1.0 (142). The current meta-analysis provides evidence of a beneficial effect of a lifestyle intervention and/or drugs in children and adolescents living with obesity or overweight, consistent with a significant reduction in body fat-but not in BMI or waist circumference-an increase in circulating adiponectin and/or a reduction in serum insulin levels and diastolic blood pressure, and a trend towards a reduction of circulating leptin and glucose levels, as well as of the HOMA-IR. This meta-analysis indicates that lifestyle interventions could reduce overweight-/obesity-associated systemic inflammation and dysmetabolism even without an apparent decrease in BMI.
已有众多研究试图在儿童和青少年中建立肥胖与压力、炎症及代谢紊乱生物标志物之间的关联。在此，我们对现有研究进行了荟萃分析，以阐明儿童和青少年肥胖与生活方式干预前后压力、炎症及代谢生理指标之间难以捉摸的关联。排除了观察性研究、荟萃分析、叙述性综述和系统评价。在总共53篇文章中，根据特定标准选出了11篇。所检测的生物标志物包括循环血糖、胰岛素、高密度脂蛋白、低密度脂蛋白、甘油三酯、脂联素、瘦素、C反应蛋白、肿瘤坏死因子-α、白细胞介素（IL）-6、收缩压和舒张压以及胰岛素抵抗稳态模型评估（HOMA-IR）。所有分析均使用IBM SPSS Statistics 28.0.1.0（142版）进行。当前的荟萃分析提供了证据，表明生活方式干预和/或药物对肥胖或超重的儿童和青少年具有有益作用，这与体脂显著减少一致，但体重指数（BMI）或腰围未减少，循环脂联素增加和/或血清胰岛素水平及舒张压降低，以及循环瘦素和血糖水平以及HOMA-IR有降低趋势。这项荟萃分析表明，即使BMI没有明显下降，生活方式干预也可以减轻与超重/肥胖相关的全身炎症和代谢紊乱。
