Elloumi M, Ben Ounis O, Makni E, Van Praagh E, Tabka Z, Lac G
Laboratory of Exercise Biology (BAPS), Blaise Pascal University, Bat Biologie B, Aubière, France.
Acta Paediatr. 2009 Sep;98(9):1487-93. doi: 10.1111/j.1651-2227.2009.01365.x. Epub 2009 Jun 1.
We investigate the effects of a 2-month weight-loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys.
Twenty-one obese adolescent boys (BMI = 30.8 +/- 3.2 kg/m(2)) completed the weight-loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipox(max)) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention.
Following the weight-loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (-38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipox(max) (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA-IR) index and Lipox(max).
In obese adolescents boys, moderate exercise training completed at Lipox(max) and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA-IR.
我们研究了一项为期2个月的减肥计划对肥胖青少年男性血浆脂联素、瘦素和抵抗素水平的影响。
21名肥胖青少年男性（BMI = 30.8±3.2 kg/m²）完成了减肥计划，包括：1/能量限制（R），2/或在最大脂肪氧化点（Lipox(max)）进行个体化运动训练（E），3/或能量限制与训练（RE）。在干预前后测量身体成分、脂肪氧化以及血浆脂联素、瘦素和抵抗素水平。
在减肥计划之后，RE组青少年的身体成分得到改善（p < 0.01），血浆脂联素增加（+73.7%，p < 0.01），血浆瘦素降低（-38.8%，p < 0.01），导致脂联素/瘦素比值（ALR）升高（+144.4%，p < 0.01），高于R组或E组。E组和RE组仅显示血浆抵抗素出现类似的显著升高（p < 0.05）以及在Lipox(max)时脂肪氧化率有显著改善（p < 0.01和p < 0.001）。此外，在RE组中，ALR与腰臀比、腰高比、抵抗素水平、稳态模型评估（HOMA-IR）指数以及Lipox(max)相关。
在肥胖青少年男性中，在Lipox(max)时进行的适度运动训练并结合能量限制可提高他们氧化脂肪的能力，这与脂联素、瘦素和抵抗素水平的正常化相关，从而改善胰岛素敏感性，较高的ALR和较低的HOMA-IR证明了这一点。
