Nelson Tracy L, Fingerlin Tasha E, Moss Laurie, Barmada M Michael, Ferrell Robert E, Norris Jill M
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA.
Ann Nutr Metab. 2007;51(3):252-7. doi: 10.1159/000104145. Epub 2007 Jun 18.
BACKGROUND/AIMS: First to determine if body mass index (BMI) or waist circumference (WC) differ by possession of the Ala allele of the peroxisome proliferator-activated receptor gamma (PPARgamma) Pro12Ala polymorphism, and second, to determine if dietary fat intake and physical activity moderate these potential relationships among Hispanic Americans from Colorado.
We studied 216 Hispanic pedigrees (1,850 nuclear families) from the San Luis Valley and Denver (mean age 50 years). The families were genotyped for the Pro12Ala polymorphism of the PPARgamma gene. BMI, WC and diabetes status were measured in the clinic, and, for diabetics, self-reported BMI at diabetes diagnosis was used. Data were analyzed using the Family-Based Association Test (FBAT). We conducted overall and stratified analyses by tertiles of monounsaturated, polyunsaturated (PUFA) and saturated (SFA) fat intake, the PUFA:SFA ratio, and physical activity. We also used generalized estimating equations (GEE) to further explore the FBAT findings.
The average BMI and WC were approximately 29 kg/m(2) and 101 cm, respectively. The frequency of the Ala allele was 13.5%. We did not find the Ala allele to be associated with BMI or WC overall (p = 0.58 and 0.23, respectively). We did find the Ala allele to be associated with increased BMI in those with high dietary PUFA and PUFA:SFA ratio (p = 0.007 and 0.01, respectively); however, these findings were not confirmed using the GEE models.
One previous study has reported the Ala allele to be associated with higher BMI among Hispanics; however, we did not find this association. Further, we could not conclude that dietary fat intake or physical activity altered any association between BMI or WC and the Ala allele.
背景/目的：首先确定过氧化物酶体增殖物激活受体γ（PPARγ）Pro12Ala多态性的Ala等位基因的携带情况是否会导致体重指数（BMI）或腰围（WC）出现差异，其次确定饮食脂肪摄入量和身体活动是否会调节科罗拉多州西班牙裔美国人之间的这些潜在关系。
我们研究了来自圣路易斯谷和丹佛的216个西班牙裔家系（1850个核心家庭）（平均年龄50岁）。对这些家庭进行PPARγ基因Pro12Ala多态性的基因分型。在诊所测量BMI、WC和糖尿病状态，对于糖尿病患者，使用糖尿病诊断时自我报告的BMI。使用基于家系的关联检验（FBAT）分析数据。我们按单不饱和脂肪、多不饱和脂肪（PUFA）和饱和脂肪（SFA）摄入量、PUFA:SFA比值以及身体活动的三分位数进行总体和分层分析。我们还使用广义估计方程（GEE）进一步探究FBAT的研究结果。
平均BMI和WC分别约为29kg/m²和101cm。Ala等位基因的频率为13.5%。我们未发现Ala等位基因总体上与BMI或WC相关（p值分别为0.58和0.23）。我们确实发现，在饮食PUFA和PUFA:SFA比值较高的人群中，Ala等位基因与BMI升高相关（p值分别为0.007和0.01）；然而，使用GEE模型未证实这些结果。
此前有一项研究报告称，Ala等位基因与西班牙裔人群中较高的BMI相关；然而，我们未发现这种关联。此外，我们无法得出饮食脂肪摄入量或身体活动会改变BMI或WC与Ala等位基因之间任何关联的结论。
