PPARγ2基因的Pro12Ala多态性从出生到成年期都对体重有调节作用。

The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood.

作者信息

Pihlajamäki Jussi, Vanhala Mauno, Vanhala Pasi, Laakso Markku

机构信息

Department of Medicine, University of Kuopio, Kuopio, Finland.

出版信息

Obes Res. 2004 Feb;12(2):187-90. doi: 10.1038/oby.2004.25.

DOI:10.1038/oby.2004.25

PMID:14981210

Abstract

OBJECTIVE

The Pro12Ala polymorphism in exon B of peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) gene has been related to obesity, insulin resistance, and risk of type 2 diabetes. In this study, the effect of the Pro12Ala polymorphism on long-term changes in weight and body composition was investigated.

RESEARCH METHODS AND PROCEDURES

The Pro12Ala polymorphism was genotyped in 311 subjects who participated in our previous population-based study. In that study, weight at birth, 7 years, 20 years, and 41 years, and ponderal index at birth and BMI and waist circumference at 41 years were recorded.

RESULTS

The Ala12 allele of the PPAR gamma 2 gene was associated with high ponderal index at birth (2.77 +/- 0.27 kg/m(3) in subjects with the Ala12Ala genotype, 2.79 +/- 0.29 kg/m(3) in subjects with the Pro12Ala genotype, and 2.63 +/- 0.25 kg/m(3) in subjects with the Pro12Pro genotype, p = 0.007, adjusted for gender) and weight at 7 years (p = 0.045) and tended to be associated with high birth weight (p = 0.094). Subjects with this allele gained less weight between 7 and 20 years (p = 0.043) and more weight between 20 and 41 years (p = 0.001) and ended up having higher waist circumference (p = 0.040) in adulthood than did subjects with the Pro12Pro genotype.

DISCUSSION

We conclude that the Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight and body composition from utero to adulthood.

摘要

目的

过氧化物酶体增殖物激活受体γ2（PPARγ2）基因外显子B中的Pro12Ala多态性与肥胖、胰岛素抵抗及2型糖尿病风险相关。本研究调查了Pro12Ala多态性对体重和身体成分长期变化的影响。

研究方法与步骤

对参与我们之前基于人群研究的311名受试者进行Pro12Ala多态性基因分型。在该研究中，记录了出生时、7岁、20岁和41岁时的体重，以及出生时的 ponderal指数、41岁时的BMI和腰围。

结果

PPARγ2基因的Ala12等位基因与出生时较高的ponderal指数（Ala12Ala基因型受试者为2.77±0.27kg/m³，Pro12Ala基因型受试者为2.79±0.29kg/m³，Pro12Pro基因型受试者为2.63±0.25kg/m³，经性别校正后p = 0.007）、7岁时的体重（p = 0.045）相关，并且倾向于与较高的出生体重相关（p = 0.094）。与Pro12Pro基因型受试者相比，携带该等位基因的受试者在7至20岁之间体重增加较少（p = 0.043），在20至41岁之间体重增加较多（p = 0.001），成年后腰围更高（p = 0.040）。