Fluhr J W, Miteva M, Primavera G, Ziemer M, Elsner P, Berardesca E
Skin Physiology Laboratory, Friedrich-Schiller University, Jena, Germany.
Skin Pharmacol Physiol. 2007;20(5):253-9. doi: 10.1159/000104423. Epub 2007 Jun 22.
BACKGROUND/PURPOSE: Cancer patients undergoing chemotherapy frequently experience skin problems such as xerosis. The aim of this study was to verify whether a concomitant treatment with an acidic washing and an acidic emollient (both pH 5.5) can significantly improve the quality of the skin in such patients.
30 adult patients on chemotherapy experiencing dry and sensitive skin were included in a controlled, monocentric, 3-week treatment trial. One forearm served as a test site, the other one remained untreated. Noninvasive biophysical measurements were performed at baseline, on days 7, 14 and 21, along with clinical evaluation of the skin symptoms.
After a 3-week treatment, a significant increase in stratum corneum hydration was recorded in the treated site (p < 0.001). Reduced transepidermal water loss values, consistent with a restored barrier function, were obtained (p < 0.001). Casual sebum levels as measured by sebumetry showed a significant increase (p < 0.03). All skin symptoms investigated revealed a considerable improvement over 3 weeks.
Controlled and regular use of a skin care system, especially an acidic one, improved skin physiology in patients undergoing chemotherapy.
背景/目的：接受化疗的癌症患者经常出现皮肤问题，如皮肤干燥。本研究的目的是验证同时使用酸性洗液和酸性润肤剂（pH均为5.5）是否能显著改善此类患者的皮肤质量。
30名皮肤干燥且敏感的成年化疗患者参与了一项为期3周的对照、单中心治疗试验。一只前臂作为测试部位，另一只前臂不进行治疗。在基线、第7天、第14天和第21天进行无创生物物理测量，并对皮肤症状进行临床评估。
经过3周的治疗，治疗部位的角质层水合作用显著增加（p < 0.001）。经皮水分流失值降低，表明屏障功能恢复（p < 0.001）。通过皮脂测量仪测得的皮脂水平显著增加（p < 0.03）。所有调查的皮肤症状在3周内都有显著改善。
有控制地定期使用皮肤护理系统，尤其是酸性护理系统，可改善化疗患者的皮肤生理状况。
