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吗啡的误解:镇静、耐受性、成瘾性。

Morphine myths: sedation, tolerance, addiction.

作者信息

Zenz M

机构信息

Department of Anaesthesiology, Intensive Care and Pain Therapy, University Clinic Bergmannsheil, Bochum, West Germany.

出版信息

Postgrad Med J. 1991;67 Suppl 2:S100-2.

PMID:1758813
Abstract

Morphine and other strong opioids are still, more than 180 years after the syntheses of morphine, not adequately used in clinical practice and many patients suffer unnecessarily severe pain in consequence. Governments limit morphine usage by legal restrictions. The underuse of morphine and its restriction in many countries is mostly due to prejudice and myths which clinical experience does not show to be true. Morphine is a very safe drug, correctly prescribed in chronic pain therapy, the only severe side effect being constipation.

摘要

在吗啡合成180多年后,吗啡和其他强效阿片类药物在临床实践中仍未得到充分使用,许多患者因此遭受不必要的剧痛。政府通过法律限制来控制吗啡的使用。在许多国家,吗啡使用不足及其受限主要是由于偏见和误解,而临床经验表明这些并非事实。吗啡是一种非常安全的药物,在慢性疼痛治疗中正确使用时,唯一的严重副作用是便秘。

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1
Morphine myths: sedation, tolerance, addiction.吗啡的误解:镇静、耐受性、成瘾性。
Postgrad Med J. 1991;67 Suppl 2:S100-2.
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Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone).阿片类药物与老年人慢性重度疼痛的管理:一个国际专家小组的共识声明,重点关注世界卫生组织第三阶梯临床最常用的六种阿片类药物(丁丙诺啡、芬太尼、氢吗啡酮、美沙酮、吗啡、羟考酮)。
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[Opiates and opioids in the treatment of tumor-related pain].[阿片类药物在肿瘤相关性疼痛治疗中的应用]
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Morphine: myths, morality and economics.吗啡:神话、道德与经济学
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Opioid tolerance and dependence -- do they matter?阿片类药物耐受性和依赖性——它们重要吗?
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Opioid use by patients in an orthopedics spine clinic.骨科脊柱诊所患者的阿片类药物使用情况。
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[Opioids in treatment of chronic noncancer pain].[阿片类药物用于慢性非癌性疼痛的治疗]
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引用本文的文献

1
Exploring the myths of morphine in cancer: views of the general practice population.探索癌症治疗中吗啡使用的误区:全科医疗人群的观点
Support Care Cancer. 2015 Feb;23(2):483-9. doi: 10.1007/s00520-014-2379-9. Epub 2014 Aug 20.
2
[Pain and anesthesiology : aspects of the development of modern pain therapy in the twentieth century].[疼痛与麻醉学:20世纪现代疼痛治疗的发展历程]
Anaesthesist. 2011 Jun;60(6):555-66. doi: 10.1007/s00101-011-1874-3.
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Pitfalls in the use of opiates in treatment of cancer pain.
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