Min Y-D, Choi C-H, Bark H, Son H-Y, Park H-H, Lee S, Park J-W, Park E-K, Shin H-I, Kim S-H
Department of Surgery, Chosun University Medical School, Gwangju, 501-759, Republic of Korea.
Inflamm Res. 2007 May;56(5):210-5. doi: 10.1007/s00011-007-6172-9.
Mast cell-mediated allergic inflammation is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1.
HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI).
Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin attenuated PMACI-induced activation of NF-kappaB and p38 mitogen-activated protein kinase.
Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic inflammatory diseases.
肥大细胞介导的过敏性炎症涉及许多疾病，如哮喘、鼻窦炎和类风湿性关节炎。肥大细胞诱导具有免疫调节特性的促炎细胞因子的产生。我们研究了槲皮素对人肥大细胞系HMC-1中促炎细胞因子表达的影响。
用佛波醇12-肉豆蔻酸酯13-乙酸酯（PMA）和钙离子载体A23187（PMACI）刺激HMC-1细胞。
槲皮素降低了PMACI刺激的HMC-1细胞中肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β、IL-6和IL-8的基因表达及产生。槲皮素减弱了PMACI诱导的核因子-κB（NF-κB）和p38丝裂原活化蛋白激酶的激活。
我们的研究提供了证据，表明槲皮素可能适用于治疗肥大细胞源性过敏性炎症疾病。
