Cozen W, Cerhan J R, Martinez-Maza O, Ward M H, Linet M, Colt J S, Davis S, Severson R K, Hartge P, Bernstein L
Department of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, MC 9175, Los Angeles, CA 90089-9175, USA.
Cancer Causes Control. 2007 Oct;18(8):821-31. doi: 10.1007/s10552-007-9025-5. Epub 2007 Jun 22.
Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case-control study of NHL.
Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk.
A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95% Confidence Interval [CI] = 0.6-1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95% CI = 0.4-0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95% CI = 1.1-3.4), but not DLBCL (OR = 1.1, 95% CI = 0.6-2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90% increased risk of DLBCL (95% CI = 1.2-3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95% CI = 0.6-1.8).
We infer that some childhood and immune-related factors may alter NHL risk.
由于成人免疫反应性受儿童早期接触因素的影响，我们在一项非霍奇金淋巴瘤（NHL）的多中心病例对照研究中，考察了家庭规模、特应性疾病史以及其他儿童期免疫相关接触因素的作用。
对从西雅图、底特律、洛杉矶和爱荷华州基于人群的癌症登记处确诊的1321例病例，以及通过随机数字拨号从医疗保险档案数据库中选取的1057例频率匹配对照进行了访谈。采用多变量逻辑回归来估计风险。
有任何过敏史（不包括药物过敏）可降低所有NHL（优势比[OR]=0.7，95%置信区间[CI]=0.6 - 1.0）、弥漫性大B细胞淋巴瘤[DLBCL]（OR = 0.6，95% CI = 0.4 - 0.9）和滤泡性NHL（OR = 0.7，95 CI = 0.5，1.0）的发病风险。花粉症也观察到类似效果。湿疹病史与滤泡性淋巴瘤发病风险增加相关（OR = 1.9，95% CI = 1.1 - 3.4），但与DLBCL无关（OR = 1.1，95% CI = 0.6 - 2.0）。哮喘不影响发病风险。与最大的兄弟姐妹相比，最小的兄弟姐妹患DLBCL的风险增加90%（95% CI = 1.2 - 3.1；出生顺序增加的趋势p值 = 0.006），但与滤泡性淋巴瘤无关（OR = 1.1，95% CI = 0.6 - 1.8）。
我们推断一些儿童期和免疫相关因素可能改变NHL发病风险。
