Yang Jia, Xu Hong'en, Liang Xiaodong, Lv Shiliang, Lin Baihua, Jia Yongshi
Department of Radiotherapy, Zhejiang Provincial People's Hospital, Hangzhou, People's Republic of China.
Onco Targets Ther. 2017 Apr 18;10:2189-2198. doi: 10.2147/OTT.S128849. eCollection 2017.
We aimed to systematically evaluate the association between allergic conditions and the risk of Hodgkin's lymphoma (HL) and non-HL (NHL). Systematic literature searches in PubMed and Embase were conducted up to October 2015 to identify eligible studies. Either a fixed-effects model or a random-effects model was adopted to estimate overall odds ratios (ORs) according to heterogeneity across studies. Subgroup and publication bias analyses were applied. A total of 24 case-control studies and 13 cohort studies (conducted from 1987 to 2015) were included in the analysis of the risk of NHL. History of any allergic condition was inversely associated with the risk of NHL in case-control studies (OR =0.83, 95% CI 0.76-0.91), while the reduction in the risk of NHL was not observed in cohort studies (OR =1.18, 95% CI 0.98-1.42). Significant association with the risk of NHL was found for asthma, hay fever, food allergy, allergic rhinitis, and hives. In the pooled analysis of the risk of HL, 12 studies (two were cohort studies) were included. The pooled OR was 0.96 (95% CI 0.84-1.09) for case-control studies and 1.46 (95% CI 0.63-3.38) for cohort studies. For specific allergic condition, we observed a reduced risk of HL in individuals with hay fever and food allergy. In conclusion, history of any allergic condition was not significantly associated with the risk of NHL or HL. Several specific allergic conditions, including asthma, hay fever, food allergy, and allergic rhinitis, might be associated with a reduced risk of NHL, while individuals with hay fever or food allergy may have a reduced risk of HL.
我们旨在系统评估过敏状况与霍奇金淋巴瘤（HL）及非霍奇金淋巴瘤（NHL）风险之间的关联。截至2015年10月，我们在PubMed和Embase数据库中进行了系统的文献检索，以确定符合条件的研究。根据各研究之间的异质性，采用固定效应模型或随机效应模型来估计总体比值比（OR）。进行了亚组分析和发表偏倚分析。共有24项病例对照研究和13项队列研究（时间跨度为1987年至2015年）纳入了NHL风险分析。在病例对照研究中，任何过敏状况的病史与NHL风险呈负相关（OR = 0.83，95%可信区间0.76 - 0.91），而在队列研究中未观察到NHL风险降低（OR = 1.18，95%可信区间0.98 - 1.42）。发现哮喘、花粉症、食物过敏、过敏性鼻炎和荨麻疹与NHL风险存在显著关联。在HL风险的汇总分析中，纳入了12项研究（其中两项为队列研究）。病例对照研究的汇总OR为0.96（95%可信区间0.84 - 1.09），队列研究的汇总OR为1.46（95%可信区间0.63 - 3.38）。对于特定的过敏状况，我们观察到花粉症和食物过敏个体的HL风险降低。总之，任何过敏状况的病史与NHL或HL风险均无显著关联。几种特定的过敏状况，包括哮喘、花粉症、食物过敏和过敏性鼻炎，可能与NHL风险降低有关，而花粉症或食物过敏个体的HL风险可能降低。
