Brunet Alain, Orr Scott P, Tremblay Jacques, Robertson Kate, Nader Karim, Pitman Roger K
Department of Psychiatry, McGill University and Douglas Hospital Research Center, Montreal, QC, Canada.
J Psychiatr Res. 2008 May;42(6):503-6. doi: 10.1016/j.jpsychires.2007.05.006. Epub 2007 Jun 22.
The beta-adrenergic blocker propranolol given within hours of a psychologically traumatic event reduces physiologic responses during subsequent mental imagery of the event. Here we tested the effect of propranolol given after the retrieval of memories of past traumatic events. Subjects with chronic post-traumatic stress disorder described their traumatic event during a script preparation session and then received a one-day dose of propranolol (n=9) or placebo (n=10), randomized and double-blind. A week later, they engaged in script-driven mental imagery of their traumatic event while heart rate, skin conductance, and left corrugator electromyogram were measured. Physiologic responses were significantly smaller in the subjects who had received post-reactivation propranolol a week earlier. Propranolol given after reactivation of the memory of a past traumatic event reduces physiologic responding during subsequent mental imagery of the event in a similar manner to propranolol given shortly after the occurrence of a traumatic event.
在心理创伤事件发生数小时内给予β-肾上腺素能阻滞剂普萘洛尔，可降低随后对该事件进行心理意象时的生理反应。在此，我们测试了在检索过去创伤事件的记忆后给予普萘洛尔的效果。患有慢性创伤后应激障碍的受试者在脚本准备阶段描述了他们的创伤事件，然后接受为期一天的普萘洛尔（n = 9）或安慰剂（n = 10）治疗，采用随机双盲方式。一周后，他们在进行脚本驱动的创伤事件心理意象时，测量心率、皮肤电导率和左侧皱眉肌肌电图。一周前接受记忆再激活后普萘洛尔治疗的受试者的生理反应明显较小。在过去创伤事件的记忆被激活后给予普萘洛尔，可降低随后对该事件进行心理意象时的生理反应，其方式与创伤事件发生后不久给予普萘洛尔相似。
