Blatný J
Oddĕlení klinické hematologie, Centrum pro trombózu a hemostázu, FN Brno.
Vnitr Lek. 2006 Mar;52 Suppl 1:68-72.
Data in Canadian registry for VTE in children show, that incidence of VTE in children is 0.07/10 000. The situation in adults--with incidence of VTE 37/10 000--is however completely different. Only 5% of VTE in children are idiopathic and less then 10% are related to hereditary prothrombotic risk factors only. In other words, more than 80% of VTE in children are somehow related to acquired prothrombotic risk factors. Despite of this, there have not been found any measures, that would be able to further decrease significantly this very low incidence of VTE in children. This is probably the reason, why to date there are no evidence based recommendations for primary prophylaxis of VTE in children and also there is no valid reason for non-selective screening for hereditary prothrombotic risk factors in population of children, who have not suffered VTE.
加拿大儿童静脉血栓栓塞症登记处的数据显示，儿童静脉血栓栓塞症的发病率为0.07/10000。然而，成人的情况——静脉血栓栓塞症发病率为37/10000——则完全不同。儿童静脉血栓栓塞症中只有5%是特发性的，且只有不到10%仅与遗传性血栓形成风险因素有关。换句话说，儿童静脉血栓栓塞症中超过80%在某种程度上与获得性血栓形成风险因素有关。尽管如此，尚未发现任何能够进一步显著降低儿童这种极低静脉血栓栓塞症发病率的措施。这可能就是为什么迄今为止没有基于证据的儿童静脉血栓栓塞症一级预防建议，而且对于未患静脉血栓栓塞症的儿童群体进行遗传性血栓形成风险因素的非选择性筛查也没有正当理由。
