Waterhouse Robert M, Kriventseva Evgenia V, Meister Stephan, Xi Zhiyong, Alvarez Kanwal S, Bartholomay Lyric C, Barillas-Mury Carolina, Bian Guowu, Blandin Stephanie, Christensen Bruce M, Dong Yuemei, Jiang Haobo, Kanost Michael R, Koutsos Anastasios C, Levashina Elena A, Li Jianyong, Ligoxygakis Petros, Maccallum Robert M, Mayhew George F, Mendes Antonio, Michel Kristin, Osta Mike A, Paskewitz Susan, Shin Sang Woon, Vlachou Dina, Wang Lihui, Wei Weiqi, Zheng Liangbiao, Zou Zhen, Severson David W, Raikhel Alexander S, Kafatos Fotis C, Dimopoulos George, Zdobnov Evgeny M, Christophides George K
Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.
Science. 2007 Jun 22;316(5832):1738-43. doi: 10.1126/science.1139862.
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
蚊子是对公共卫生极为重要的寄生虫病和病毒病的传播媒介。黄热病和登革热传播媒介埃及伊蚊（Aa）基因组序列的获得，使得对昆虫免疫库进行比较系统发育基因组分析成为可能：涉及埃及伊蚊、疟疾传播媒介冈比亚按蚊（Ag）以及果蝇（Dm）。对免疫信号通路和反应模块的分析揭示了与不同功能基因类别以及免疫反应特定方面相关的保守和快速进化特征。这些动态变化部分反映了在病原体的容纳与排斥之间的持续重新调整，并提示了固有免疫可能的进化方式。
