Nene Vishvanath, Wortman Jennifer R, Lawson Daniel, Haas Brian, Kodira Chinnappa, Tu Zhijian Jake, Loftus Brendan, Xi Zhiyong, Megy Karyn, Grabherr Manfred, Ren Quinghu, Zdobnov Evgeny M, Lobo Neil F, Campbell Kathryn S, Brown Susan E, Bonaldo Maria F, Zhu Jingsong, Sinkins Steven P, Hogenkamp David G, Amedeo Paolo, Arensburger Peter, Atkinson Peter W, Bidwell Shelby, Biedler Jim, Birney Ewan, Bruggner Robert V, Costas Javier, Coy Monique R, Crabtree Jonathan, Crawford Matt, Debruyn Becky, Decaprio David, Eiglmeier Karin, Eisenstadt Eric, El-Dorry Hamza, Gelbart William M, Gomes Suely L, Hammond Martin, Hannick Linda I, Hogan James R, Holmes Michael H, Jaffe David, Johnston J Spencer, Kennedy Ryan C, Koo Hean, Kravitz Saul, Kriventseva Evgenia V, Kulp David, Labutti Kurt, Lee Eduardo, Li Song, Lovin Diane D, Mao Chunhong, Mauceli Evan, Menck Carlos F M, Miller Jason R, Montgomery Philip, Mori Akio, Nascimento Ana L, Naveira Horacio F, Nusbaum Chad, O'leary Sinéad, Orvis Joshua, Pertea Mihaela, Quesneville Hadi, Reidenbach Kyanne R, Rogers Yu-Hui, Roth Charles W, Schneider Jennifer R, Schatz Michael, Shumway Martin, Stanke Mario, Stinson Eric O, Tubio Jose M C, Vanzee Janice P, Verjovski-Almeida Sergio, Werner Doreen, White Owen, Wyder Stefan, Zeng Qiandong, Zhao Qi, Zhao Yongmei, Hill Catherine A, Raikhel Alexander S, Soares Marcelo B, Knudson Dennis L, Lee Norman H, Galagan James, Salzberg Steven L, Paulsen Ian T, Dimopoulos George, Collins Frank H, Birren Bruce, Fraser-Liggett Claire M, Severson David W
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Science. 2007 Jun 22;316(5832):1718-23. doi: 10.1126/science.1138878. Epub 2007 May 17.
We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
我们展示了埃及伊蚊的基因组草图序列，埃及伊蚊是黄热病和登革热的主要传播媒介，其基因组约有13.76亿个碱基对，大约是疟蚊冈比亚按蚊基因组大小的5倍。埃及伊蚊基因组近50%由转座元件组成。相对于冈比亚按蚊和黑腹果蝇，这些转座元件导致平均基因长度和基因间区域大小增加了约4至6倍。尽管如此，这三种昆虫的染色体同线性总体上得以维持，不过，与果蝇相比，两种蚊类之间直系同源基因顺序的保守性更高（约为2倍）。相对于冈比亚按蚊，编码气味结合蛋白、细胞色素P450和表皮结构域的基因有所增加，这表明这些蛋白质家族的成员构成了这两种蚊类之间一些生物学差异的基础。
