从眼部感染分离出的耐甲氧西林和甲氧西林敏感凝固酶阴性葡萄球菌对氟喹诺酮类药物的敏感性
Fluoroquinolone susceptibilities to methicillin-resistant and susceptible coagulase-negative Staphylococcus isolated from eye infection.
作者信息
Oliveira Adália Dias Dourado, Höfling-Lima Ana Luisa, Belfort Rubens, Gayoso Maria de Fátima, Francisco Waldemar
机构信息
Universidade Federal de São Paulo, São Paulo, SP, Brasil.
出版信息
Arq Bras Oftalmol. 2007 Mar-Apr;70(2):286-9. doi: 10.1590/s0004-27492007000200018.
PURPOSE
To evaluate the fluoroquinolone susceptibilities of ocular isolate coagulase-negative staphylococci (CoNS), identified at the Microbiology Laboratory - UNIFESP.
DESIGN
Experimental laboratory investigation.
METHODS
The minimum inhibitory concentrations (MICs) of 21 strains of methicillin-resistant coagulase-negative staphylococci (MRCoNS) and 22 methicillin-sensitive coagulase-negative staphylococci (MSCoNS) to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin were determined, using the E-test method standardized by the Clinical and Laboratory Standards Institute (CLSI/NCCLS).
RESULTS
The MIC90s (microg/ml) for the second generation of tested fluoroquinolones were higher than the fourth generation, especially for the methicillin-resistant coagulase-negative staphylococci group.
CONCLUSION
Our results indicate that methicillin-sensitive coagulase-negative staphylococci are more susceptible to quinolones than are methicillin-resistant coagulase-negative staphylococci and that fourth generation fluoroquinolones appear to be more potent, affecting even coagulase-negative staphylococcal strains resistant to second generation fluoroquinolones.
目的
评估在联邦圣保罗大学微生物实验室鉴定出的眼部分离凝固酶阴性葡萄球菌（CoNS）对氟喹诺酮类药物的敏感性。
设计
实验性实验室研究。
方法
采用临床和实验室标准协会（CLSI/NCCLS）标准化的E-test法，测定21株耐甲氧西林凝固酶阴性葡萄球菌（MRCoNS）和22株甲氧西林敏感凝固酶阴性葡萄球菌（MSCoNS）对环丙沙星、氧氟沙星、加替沙星和莫西沙星的最低抑菌浓度（MICs）。
结果
第二代测试氟喹诺酮类药物的MIC90s（微克/毫升）高于第四代，尤其是耐甲氧西林凝固酶阴性葡萄球菌组。
结论
我们的结果表明，甲氧西林敏感凝固酶阴性葡萄球菌比耐甲氧西林凝固酶阴性葡萄球菌对喹诺酮类药物更敏感，并且第四代氟喹诺酮类药物似乎更有效，甚至对第二代氟喹诺酮类药物耐药的凝固酶阴性葡萄球菌菌株也有影响。
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