Takahashi T, Sawai K, Hagiwara A, Takahashi S, Seiki K, Tokuda H
Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Semin Surg Oncol. 1991 Nov-Dec;7(6):378-83. doi: 10.1002/ssu.2980070610.
Activated carbon particles are taken selectively up by lymphatics when injected into the tissues and visualize regional lymph nodes colored black. Furthermore, carbon particles adsorb a large amount of the anticancer agent mitomycin C (MMC) on their surface and release the drug reversibly. Using these properties of activated carbon particles, we have applied it for lymph node dissection and chemotherapy of lymph node metastasis. After injection of carbon particles, regional lymph nodes of the stomach were found to be black; blackened lymph nodes extending widely from perigastric to para-aortic nodes were identified from other structures. Four hundred and twenty-four patients with gastric cancer were treated with this method for lymph node metastasis during 1984-1988. Involved nodes were generally colored in high incidence, about 70% of involved ones except for highly positive nodes, which was the same as noninvolved nodes. In highly positive nodes, the colored incidence was decreased to about 48%. The cumulative 5-year survival rate of the patients treated with this series was 74.6%, which was significantly higher than the figures without this method.
当活性炭颗粒注入组织时，会被淋巴管选择性摄取，使区域淋巴结呈现黑色。此外，活性炭颗粒表面可吸附大量抗癌药物丝裂霉素C（MMC），并能可逆性释放药物。利用活性炭颗粒的这些特性，我们将其应用于淋巴结清扫及淋巴结转移的化疗。注入活性炭颗粒后，发现胃的区域淋巴结变黑；从胃周延伸至主动脉旁的广泛变黑的淋巴结可与其他结构区分开来。1984年至1988年期间，424例胃癌患者采用该方法治疗淋巴结转移。受累淋巴结通常有较高的着色率，除高度阳性淋巴结外，约70%的受累淋巴结着色，这与未受累淋巴结相同。在高度阳性淋巴结中，着色率降至约48%。该系列治疗患者的累积5年生存率为74.6%，显著高于未采用该方法的生存率。
