Prescrire Int. 2007 Jun;16(89):112-3.
(1) Oral steroids can damage the skin. Cutaneous thinning and bruising have also been reported with inhaled steroids. (2) A randomised double-blind placebo-controlled trial of inhaled triamcinolone in chronic obstructive pulmonary disease provides useful data on the frequency of such effects. (3) The frequency of bruising was 11.2% with the steroid and 3.7% with placebo, while delayed wound healing occurred in respectively 2.4% and 0.5% of patients. These cutaneous adverse effects were dose-dependent and increased with age. (4) The inhaled route does not prevent steroid adverse effects occurring at a distance from the airways. This is one more reason for using the minimal effective dose of inhaled steroids, especially in older patients.
(1) 口服类固醇会损害皮肤。吸入性类固醇也会导致皮肤变薄和瘀伤。(2) 一项关于吸入曲安奈德治疗慢性阻塞性肺疾病的随机双盲安慰剂对照试验，提供了关于此类影响发生频率的有用数据。(3) 使用类固醇的患者瘀伤发生率为11.2%，使用安慰剂的患者为3.7%，而伤口愈合延迟分别发生在2.4%和0.5%的患者中。这些皮肤不良反应具有剂量依赖性，并随年龄增长而增加。(4) 吸入途径并不能防止气道以外部位出现类固醇不良反应。这是使用最小有效剂量吸入性类固醇的又一个原因，尤其是在老年患者中。
