淋巴结转移作为Borrmann I型胃癌患者的单一预测指标。

Lymph node metastasis as a single predictor in patients with Borrmann type I gastric cancer.

作者信息

Chen Jen-Hao, Wu Chew-Wun, Lo Su-Shun, Li Anna F Y, Hsieh Mao-Chin, Shen King-Han, Lui Wing-Yiu

机构信息

Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University, Shih-Pai Rd., 201, Taipei 11217, Taiwan.

出版信息

Hepatogastroenterology. 2007 Apr-May;54(75):981-4.

PMID:17591108

Abstract

BACKGROUND/AIMS: Borrmann type I gastric cancers are rare. Its clinicopathological features have never been reported.

METHODOLOGY

A total of 33 patients with Borrmann type I gastric cancer was evaluated. 570 patients with Borrmann type II, III and IV were used as references.

RESULTS

Borrmann type I gastric cancer occurred preferably in upper stomach, and had more T1 and T2 cancer invasion and early TNM stages, but less lymph node metastasis. Histologically, it had more intestinal type and less scirrhous stromal reaction. Five-year disease-free and overall survival rates in patients with Borrmann type I tumors were significantly higher than that of other types (73.3% vs. 45.8%; P = 0.02, and 72.6% vs. 47.8%; P = 0.01, respectively). Analysis of the relation between clinicopathological factors and survival showed that only lymph node metastasis significantly affected on disease-free survival with a relative risk of 8.4. Lymph node metastasis also affected overall survival rate at a marginal level (p = 0.05).

CONCLUSIONS

Borrmann type I gastric cancer has higher survival rate. Lymph node metastasis is a single prognostic indicator for survival.

摘要

背景/目的：Borrmann I型胃癌较为罕见。其临床病理特征此前从未有过报道。

方法

共评估了33例Borrmann I型胃癌患者。选取570例Borrmann II型、III型和IV型患者作为对照。

结果

Borrmann I型胃癌好发于胃上部，T1和T2期癌浸润及TNM早期阶段更多，但淋巴结转移较少。组织学上，肠型更多，硬癌间质反应较少。Borrmann I型肿瘤患者的5年无病生存率和总生存率显著高于其他类型（分别为73.3%对45.8%；P = 0.02，以及72.6%对47.8%；P = 0.01）。对临床病理因素与生存关系的分析表明，只有淋巴结转移对无病生存有显著影响，相对风险为8.4。淋巴结转移对总生存率也有一定程度的影响（p = 0.05）。