Li Chen, Oh Sung Jin, Kim Sungsoo, Hyung Woo Jin, Yan Min, Zhu Zheng Gang, Noh Sung Hoon
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Oncology. 2009;77(3-4):197-204. doi: 10.1159/000236018. Epub 2009 Sep 3.
The purpose of this study was to clarify the clinical significance of macroscopic Borrmann type in advanced gastric cancer.
From 1987 to 2001, we retrospectively studied the clinicopathological features and prognoses of 3,966 patients with advanced gastric cancer according to the macroscopic classification of Borrmann type.
Multivariate analysis showed that gender, Borrmann type and depth of invasion were all associated with the status of nodal involvement. There were statistically significant differences in overall survival among patients with Borrmann type I and II tumors, Borrmann type III tumors, and Borrmann type IV tumors according to depth of invasion (pT) and nodal involvement (pN), except in pN3 tumors. Borrmann type was an independent prognostic factor in patients with advanced gastric cancer. Furthermore, the 5-year survival rates of patients with Borrmann type III and type IV tumors after curative resection were 62.0 and 51.2%, respectively; this was significantly higher than after noncurative resection (17.8 and 18.0%, respectively).
Macroscopic Borrmann type is a simple and valuable predictor for lymph node metastasis and survival in advanced gastric cancer patients.
本研究旨在阐明进展期胃癌中Borrmann大体分型的临床意义。
1987年至2001年，我们根据Borrmann大体分型对3966例进展期胃癌患者的临床病理特征及预后进行了回顾性研究。
多因素分析显示，性别、Borrmann分型及浸润深度均与淋巴结受累情况相关。根据浸润深度（pT）和淋巴结受累情况（pN），Borrmann I型和II型肿瘤患者、Borrmann III型肿瘤患者以及Borrmann IV型肿瘤患者的总生存率存在统计学显著差异，但pN3肿瘤患者除外。Borrmann分型是进展期胃癌患者的独立预后因素。此外，Borrmann III型和IV型肿瘤患者根治性切除后的5年生存率分别为62.0%和51.2%；这显著高于非根治性切除后的生存率（分别为17.8%和18.0%）。
Borrmann大体分型是进展期胃癌患者淋巴结转移及生存情况的一个简单且有价值的预测指标。
