台湾耐青霉素肺炎链球菌分离株中头孢曲松耐药性增加及青霉素结合蛋白的多种改变
Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan.
作者信息
Chiu Cheng-Hsun, Su Lin-Hui, Huang Yhu-Chering, Lai Jui-Chia, Chen Hsiu-Ling, Wu Tsu-Lan, Lin Tzou-Yien
机构信息
Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan.
出版信息
Antimicrob Agents Chemother. 2007 Sep;51(9):3404-6. doi: 10.1128/AAC.01563-06. Epub 2007 Jun 25.
Abstract
The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.
摘要
2005年，台湾地区耐青霉素肺炎链球菌菌株对头孢曲松的不敏感率显著上升。约90%对头孢曲松不敏感的分离株被发现属于四种主要血清型（血清型6B、14、19F和23F）。青霉素结合蛋白2B转肽酶编码区域的七个氨基酸改变特别导致了耐药性。
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