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[免疫复合物中的胆固醇含量作为冠状动脉和外周动脉粥样硬化的标志物]

[The cholesterol content in immune complexes as a marker of coronary and peripheral atherosclerosis].

作者信息

Kalenich O S, Tertov V V, Liakishev A A, Ruda M Ia, Orekhov A N

出版信息

Ter Arkh. 1991;63(9):59-61.

PMID:1759226
Abstract

As many as 107 patients with coronary atherosclerosis, 66 with peripheral atherosclerosis, 27 with unaltered coronary arteries and 30 healthy blood donors were examined. The content of cholesterol in immune complexes was significantly higher in patients with coronary and peripheral atherosclerosis as compared to patients with intact arteries and healthy subjects. The highest content of cholesterol in immune complexes was detected in patients with combined lesions of coronary arteries and arteries of the lower limbs. It exceeded 3.5-5.5-fold the content of cholesterol in immune complexes in the control groups. The accuracy of the diagnosis with the aid of measuring the content of cholesterol in immune complexes in atherosclerosis of any sites was equal to 85%, in peripheral atherosclerosis to 89%, which slightly exceeded the diagnosis accuracy in atherosclerosis of coronary arteries (83%).

摘要

对多达107例冠状动脉粥样硬化患者、66例外周动脉粥样硬化患者、27例冠状动脉未改变的患者和30名健康献血者进行了检查。与动脉正常的患者和健康受试者相比,冠状动脉和外周动脉粥样硬化患者免疫复合物中的胆固醇含量显著更高。在冠状动脉和下肢动脉合并病变的患者中,检测到免疫复合物中胆固醇含量最高。它超过对照组免疫复合物中胆固醇含量的3.5至5.5倍。借助测量任何部位动脉粥样硬化中免疫复合物中胆固醇含量进行诊断的准确性在动脉粥样硬化中为85%,在外周动脉粥样硬化中为89%,略高于冠状动脉粥样硬化的诊断准确性(83%)。

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