Orekhov A N, Kalenich O S, Tertov V V, Novikov I D
Institute of Experimental Cardiology, USSR Cardiology Research Centre, Moscow.
Int J Tissue React. 1991;13(5):233-6.
Recently we have demonstrated that cholesterol level in LDL-containing circulating immune complexes (CIC cholesterol) correlates with the presence of coronary atherosclerosis. In the present study we attempted to clarify whether CIC cholesterol level correlates with the severity of coronary atherosclerosis. The second task was to reveal the diagnostic value of CIC cholesterol in comparison with other lipid and lipoprotein parameters used as markers of dislipidaemia associated with atherosclerosis. The subjects were 107 patients with angiographically-documented coronary atherosclerosis and 66 patients with documented extracoronary atherosclerosis. Only CIC cholesterol and the apo B/apo A-1 ratio contributed strongly to the discrimination between patients with coronary atherosclerosis and those without stenoses. On the other hand, total cholesterol, triglycerides, HDL cholesterol, apo B, Lp[a] and apo A1 did not correlate with the presence and severity of coronary atherosclerosis. Subjects with stenosis of extracoronary arteries had significantly higher CIC levels than healthy donors. Sensitivity, specificity and accuracy of coronary atherosclerosis diagnosis were assessed for each parameter examined. It was revealed that CIC cholesterol is the most reliable marker of coronary atherosclerosis as compared to other chemical parameters. In addition, the CIC cholesterol level diagnoses extracoronary atherosclerosis with high accuracy.
最近我们已经证明，含低密度脂蛋白的循环免疫复合物中的胆固醇水平（CIC胆固醇）与冠状动脉粥样硬化的存在相关。在本研究中，我们试图阐明CIC胆固醇水平是否与冠状动脉粥样硬化的严重程度相关。第二项任务是揭示CIC胆固醇与用作动脉粥样硬化相关血脂异常标志物的其他脂质和脂蛋白参数相比的诊断价值。研究对象为107例经血管造影证实有冠状动脉粥样硬化的患者和66例经证实有冠状动脉外粥样硬化的患者。只有CIC胆固醇和载脂蛋白B/载脂蛋白A-1比值对区分有冠状动脉粥样硬化的患者和无狭窄的患者有很大贡献。另一方面，总胆固醇、甘油三酯、高密度脂蛋白胆固醇、载脂蛋白B、脂蛋白[a]和载脂蛋白A1与冠状动脉粥样硬化的存在和严重程度无关。冠状动脉外动脉狭窄的患者CIC水平明显高于健康对照者。对所检查的每个参数评估冠状动脉粥样硬化诊断的敏感性、特异性和准确性。结果显示，与其他化学参数相比，CIC胆固醇是冠状动脉粥样硬化最可靠的标志物。此外，CIC胆固醇水平对冠状动脉外粥样硬化的诊断具有很高的准确性。
