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精神分裂症的心理教育:慕尼黑精神病信息项目研究中关于再次住院和住院天数的7年随访

Psychoeducation in schizophrenia: 7-year follow-up concerning rehospitalization and days in hospital in the Munich Psychosis Information Project Study.

作者信息

Bäuml Joseph, Pitschel-Walz Gabriele, Volz Anja, Engel Rolf R, Kessling Werner

机构信息

Hospital of Psychiatry and Psychotherapy, Technical University of Munich, Germany.

出版信息

J Clin Psychiatry. 2007 Jun;68(6):854-61.

Abstract

OBJECTIVE

According to most of the relevant guidelines, psychoeducation is considered a basic part of routine therapy for patients with schizophrenia; scientific proofs of its efficacy are based mainly on the results of 1- and 2-year follow-ups. Therefore, the long-term effects of psychoeducation over a period of 7 years were investigated in regard to rehospitalization rates and hospital days.

METHOD

Of 101 patients with DSM-III-R or ICD-9 schizophrenia randomly allocated to either an intervention group or a control group between 1990 and 1994, 48 patients were available for follow-up after 7 years. During their index stay, the 24 patients of the intervention group and their key relatives each received a separate psychoeducational group therapy. The 24 patients of the control group received the usual treatment. After index discharge, all 48 patients received a comparable outpatient treatment. Main outcome measures were rehospitalization rate, number of intervening hospital days, compliance, and mean number of consumed chlorpromazine (CPZ) units.

RESULTS

Seven years after index discharge, the rate of rehospitalization was 54% in the intervention group and 88% in the control group. The rate of rehospitalization per patient was 1.5 in the intervention group and 2.9 in the control group (p < .05). In the intervening period, the mean number of hospital days spent in a psychiatric hospital was 75 in the intervention group and 225 days in the control group. (p < .05). The mean number of consumed CPZ units after 7 years was 354 in the intervention and 267 in the control group.

CONCLUSIONS

Seven years after psychoeducational group therapy, significant effects on the long-term course of the illness can be found. Therefore, the integration of psychoeducation into standard therapy for schizophrenia should become obligatory.

摘要

目的

根据大多数相关指南,心理教育被视为精神分裂症患者常规治疗的基本组成部分;其疗效的科学证据主要基于1年和2年随访结果。因此,研究了心理教育在7年期间对再住院率和住院天数的长期影响。

方法

1990年至1994年间,101例符合DSM-III-R或ICD-9精神分裂症诊断标准的患者被随机分为干预组或对照组,7年后有48例患者可供随访。在其首次住院期间,干预组的24例患者及其主要亲属分别接受了单独的心理教育团体治疗。对照组的24例患者接受常规治疗。首次出院后,所有48例患者均接受了类似的门诊治疗。主要观察指标为再住院率、干预住院天数、依从性以及氯丙嗪(CPZ)平均消耗量。

结果

首次出院7年后,干预组的再住院率为54%,对照组为88%。干预组患者的再住院率为1.5,对照组为2.9(p<0.05)。在此期间,干预组患者在精神病院的平均住院天数为75天,对照组为225天(p<0.05)。7年后,干预组CPZ平均消耗量为354,对照组为267。

结论

心理教育团体治疗7年后,可发现对疾病的长期病程有显著影响。因此,应将心理教育纳入精神分裂症的标准治疗中。

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