Levisianou D, Melidonis A, Adamopoulou E, Skopelitis E, Koutsovasilis A, Protopsaltis I, Zairis M, Kougialis S, Skoularigis I, Koukoulis G, Foussas S, Triposkiadis F
Diabetes outpatient clinic, Tzanio General Hospital, Piraeus, Greece.
Int Angiol. 2009 Dec;28(6):490-5.
Arterial stiffness (AS) is a risk marker of atherosclerosis and coronary artery disease, yet its association with metabolic syndrome (MS) in diabetic patients is not established. The aim of this study was to investigate possible association of MS or its components with AS in diabetic population and to identify the MS definition which better correlates with AS.
Overall, 98 type-2 diabetic men, mean age 64+/-10 years, were classified into groups according to the presence of MS, using the National Cholesterol Educational Program-Adult Treatment Panel III (NCEP-ATPIII) and International Diabetes Federation (IDF) definition. AS was estimated using carotid-femoral pulse wave velocity (PWV). For between-group comparisons and correlations between MS and it's components with AS, t-test and Pearson's correlation coefficient were employed, respectively. For multivariable analysis a linear regression model was used.
PWV in those with (72.5%) and without NCEP-ATPIII MS was 13.4+/-2.9 vs 12+/-3.2 m/s (P=NS) and in those with (79.6%) and without IDF MS 13.6+/-2.8 vs 11+/-3.2 m/s (P=0.036). AS positively correlated with IDF MS (r=0.332, P=0.036), increased blood pressure (r=0.324, P=0.037), and the combination of increased waist circumference according to IDF with hypertension (r=0.380, P=0.013); no correlation with NCEP-ATPIII MS was detected. In multivariable analysis, age, hypertension, and IDF MS were independently associated with AS (beta=2.52, P=0.039).
IDF MS is independently associated with increased AS in diabetic men. Additionally, abdominal obesity, hypertension and older age were likely to be associated with increased AS. PWV measurement may be indicated in such patients.
动脉僵硬度（AS）是动脉粥样硬化和冠状动脉疾病的风险标志物，但其与糖尿病患者代谢综合征（MS）的关联尚未明确。本研究旨在探讨糖尿病患者中MS或其组分与AS之间的可能关联，并确定与AS相关性更好的MS定义。
总共98名2型糖尿病男性，平均年龄64±10岁，根据是否存在MS，采用美国国家胆固醇教育计划成人治疗专家组第三次报告（NCEP-ATPIII）和国际糖尿病联盟（IDF）的定义进行分组。使用颈股脉搏波速度（PWV）评估AS。对于组间比较以及MS及其组分与AS之间的相关性，分别采用t检验和Pearson相关系数。多变量分析采用线性回归模型。
患有（72.5%）和未患有NCEP-ATPIII MS者的PWV分别为13.4±2.9和12±3.2 m/s（P=无显著性差异），患有（79.6%）和未患有IDF MS者的PWV分别为13.6±2.8和11±3.2 m/s（P=0.036）。AS与IDF MS呈正相关（r=0.332，P=0.036），与血压升高（r=0.324，P=0.037）以及IDF定义的腰围增加与高血压的组合呈正相关（r=0.380，P=0.013）；未检测到与NCEP-ATPIII MS的相关性。在多变量分析中，年龄、高血压和IDF MS与AS独立相关（β=2.52，P=0.039）。
IDF MS与糖尿病男性AS增加独立相关。此外，腹型肥胖、高血压和老年可能与AS增加有关。此类患者可能需要进行PWV测量。
