Pelikan Harold M P, Bijlsma Emilia K, van Wijngaarden Willem J
Department of Obstetrics and Gynaecology, University Hospital Maastricht (AZM), P. O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Arch Gynecol Obstet. 2007 Nov;276(5):533-5. doi: 10.1007/s00404-007-0378-5. Epub 2007 Jun 26.
Case report of a rare combination of a trisomy 18 and 21 in a dizygotic twin pregnancy in a woman with a history of recurrent miscarriage, a neonatal death, no living offspring and Graves disease.
Case report and literature search.
Only one other report in the literature of a combined trisomy 18 and 21 twin pregnancy was found.
The combination of a trisomy 18 and 21 in a dizygotic twin pregnancy is very rare. Despite the high frequency and clinical importance of aneuploidy, very little is known about the factors that may modulate meiotic non-disjunction.
报告一例双卵双胎妊娠中18三体和21三体罕见组合的病例，该孕妇有复发性流产史、新生儿死亡史，无存活后代，且患有格雷夫斯病。
病例报告及文献检索。
文献中仅发现另一例18三体和21三体合并双胎妊娠的报告。
双卵双胎妊娠中18三体和21三体的组合非常罕见。尽管非整倍体的发生率很高且具有临床重要性，但对于可能调节减数分裂不分离的因素知之甚少。
