Isada N B, Bolan J C, Larsen J W, Kent S G
Department of Obstetrics and Gynecology, George Washington University Medical Center, Washington, DC 20037.
Teratology. 1990 Oct;42(4):333-6. doi: 10.1002/tera.1420420402.
Trisomy 22 (47, XY, +22) was found at 17 weeks gestation in one fetus of a twin gestation. The karyotypes of both parents and of the other twin were normal. Abnormal prenatal findings included maternal pre-eclampsia, fetal growth retardation, and progressive intracranial sonolucency of the trisomic fetus. Delivery by cesarean section at 36 weeks gestation yielded a normal healthy female weighing 2,822 grams and a markedly macerated dysmorphic male weighing 642 grams. Holoprosencephaly was found in the trisomic fetus, an unusual feature in trisomy 22. Additional findings in this case are compared to other findings in the literature.
在双胎妊娠的一个胎儿孕17周时发现22三体（47, XY, +22）。父母双方及另一胎儿的核型均正常。产前异常表现包括母亲子痫前期、胎儿生长受限以及三体胎儿进行性颅内透声。孕36周行剖宫产分娩出一名体重2822克的健康正常女婴和一名体重642克、明显浸软变形的男婴。在三体胎儿中发现了前脑无裂畸形，这在22三体中是不常见的特征。将该病例的其他发现与文献中的其他发现进行了比较。
