Hanagiri Takeshi, Sugio Kenji, Uramoto Hidetaka, So Tetsuya, Ichiki Yoshinobu, Sugaya Masakazu, Ono Kenji, Yasuda Manabu, Nozoe Tadahiro, Yasumoto Kosei
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, 807-8555, Japan.
Surg Today. 2007;37(7):546-51. doi: 10.1007/s00595-006-3453-9. Epub 2007 Jun 26.
We studied the effects of gender difference on the incidence of lung cancer and its mortality rate, which is a subject of much discussion.
We examined gender difference in the clinical features of 491 men and 222 women who underwent resection of primary non-small cell lung cancer (NSCLC) between 1994 and 2004.
The histological types of cancer were adenocarcinoma in 249 (51%) of the men and 182 (82%) of the women, and squamous cell carcinoma in 182 (37%) of the men and 27 (12%) of the women. The incidence of adenocarcinoma was significantly higher in the women. The proportion of stage IA disease was significantly higher in the women than in the men (45% vs 29%, respectively). The 5-year overall survival rates were 50% in the men and 63% in the women. In a multivariate analysis, gender difference was an independent prognostic factor; however, when death as a result of unrelated disease was excluded, there was no significant difference in prognosis.
Although the higher incidences of adenocarcinoma and stage IA cancer contributed to the good results of surgery in women, the low incidence of death attributed to diseases other than lung cancer was a major reason for their better prognosis.
我们研究了性别差异对肺癌发病率及其死亡率的影响，这是一个备受讨论的课题。
我们调查了1994年至2004年间接受原发性非小细胞肺癌（NSCLC）切除术的491名男性和222名女性患者临床特征中的性别差异。
癌症的组织学类型中，男性有249例（51%）为腺癌，女性有182例（82%）为腺癌；男性有182例（37%）为鳞状细胞癌，女性有27例（12%）为鳞状细胞癌。腺癌的发病率在女性中显著更高。IA期疾病的比例在女性中显著高于男性（分别为45%和29%）。男性的5年总生存率为50%，女性为63%。在多变量分析中，性别差异是一个独立的预后因素；然而，当排除因非相关疾病导致的死亡时，预后没有显著差异。
虽然腺癌和IA期癌症的较高发病率促成了女性手术的良好结果，但肺癌以外疾病导致的低死亡率是她们预后较好的主要原因。
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