Galvan-Ramirez M L, Rivera N, Loeza M E, Avila X, Acero J, Troyo R, Bernal R
Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
J Helminthol. 2007 Sep;81(3):255-9. doi: 10.1017/S0022149X07747466. Epub 2007 Jun 27.
Intestinal parasites in Mexico are an endemic problem. A study was conducted in children, teenagers and adults in a rural community in Colima, Mexico to examine the prevalence and intensity of Ascaris lumbricoides infection and to evaluate the parasitological and clinical efficacy of nitazoxanide (NTZ). Two hundred and eighty children, teenagers and adults participated in this study. Parasitological diagnosis from faeces was confirmed by three consecutive stool samples using the floatation concentration Faust method. Egg counts were performed as described by the Kato-Katz technique before and after treatment. A questionnaire was systematically applied to obtain information about socio-economic status and hygienic habits. One hundred and six participants (38%) were diagnosed as harbouring intestinal parasites, and 86 of them (81%) were infected with A. lumbricoides. All patients with ascariasis infections underwent a complete physical examination before and after NTZ treatment. NTZ resolved 88% of the ascariasis cases, with a 89% clinical efficacy, and there was a 97.5% reduction in the levels of morbidity. The most intense infections for A. lumbricoides were found in housewives, and statistically significant associations were found between ascariasis and the absence of drainage and living in houses with dirt floors.
墨西哥的肠道寄生虫问题呈地方性流行。在墨西哥科利马州的一个农村社区对儿童、青少年和成年人进行了一项研究，以调查蛔虫感染的患病率和感染强度，并评估硝唑尼特（NTZ）的寄生虫学和临床疗效。280名儿童、青少年和成年人参与了这项研究。采用浮聚浓缩法，通过连续三份粪便样本确诊粪便中的寄生虫学诊断。治疗前后按照加藤厚涂片法进行虫卵计数。系统地应用问卷来获取有关社会经济状况和卫生习惯的信息。106名参与者（38%）被诊断为携带肠道寄生虫，其中86人（81%）感染了蛔虫。所有蛔虫感染患者在接受NTZ治疗前后均进行了全面的体格检查。NTZ治愈了88%的蛔虫病病例，临床疗效为89%，发病率降低了97.5%。家庭主妇中蛔虫感染最为严重，并且发现蛔虫病与没有排水设施以及居住在泥土地面房屋之间存在统计学上的显著关联。
