Ceelen Manon, van Weissenbruch Mirjam M, Roos Jan C, Vermeiden Jan P W, van Leeuwen Flora E, Delemarre-van de Waal Henriette A
Departments of Paediatrics, Institute for Clinical and Experimental Neuroscience, VU University Medical Center, 1081 HV Amsterdam, The Netherlands.
J Clin Endocrinol Metab. 2007 Sep;92(9):3417-23. doi: 10.1210/jc.2006-2896. Epub 2007 Jun 26.
Increasing evidence suggests that adverse conditions during prenatal life are associated with the development of chronic diseases in adult life. It is still unclear whether in vitro fertilization (IVF) conception could affect the vulnerable developmental processes in humans occurring during early prenatal development with long-term perturbations of developmental pathways.
Our objective was to examine body composition in 8- to 18-yr-old IVF singletons and spontaneously conceived controls born from subfertile parents.
This follow-up study was conducted at the VU University Medical Center in Amsterdam, The Netherlands.
Participants included 233 IVF children (139 pubertal children) and 233 age- and gender-matched control children (143 pubertal children).
Body composition measures were assessed by anthropometry and dual-energy x-ray absorptiometry in the pubertal subpopulation.
IVF children had a significantly lower subscapular-triceps skinfold ratio and a significantly higher sum of peripheral skinfolds, peripheral body mass, and percentage of peripheral body fat as compared with controls. Although not reaching statistical significance, both dual-energy x-ray absorptiometry and skinfold measurements suggested that total body fat in IVF children is increased. Neither current and early risk factors nor parental factors, such as subfertility cause, could explain the differences in peripheral fat assessed by anthropometry between IVF children and controls. No differences in bone mineral composition between IVF children and controls were found.
Our observations indicate that body fat composition in IVF children is disturbed. Follow-up of IVF children to monitor body fat pattern and potentially related health problems from adolescence into adulthood is of great importance.
越来越多的证据表明，产前不良状况与成年期慢性病的发生有关。体外受精（IVF）受孕是否会影响人类产前早期发育过程中发生的脆弱发育过程，并导致发育途径的长期紊乱，目前尚不清楚。
我们的目的是研究8至18岁的体外受精单胎以及由不育父母自然受孕出生的对照儿童的身体组成情况。
这项随访研究在荷兰阿姆斯特丹的VU大学医学中心进行。
参与者包括233名体外受精儿童（139名青春期儿童）和233名年龄及性别匹配的对照儿童（143名青春期儿童）。
通过人体测量和双能X线吸收法对青春期亚组的身体组成指标进行评估。
与对照组相比，体外受精儿童的肩胛下-肱三头肌皮褶厚度比值显著降低，外周皮褶厚度总和、外周体重和外周体脂百分比显著升高。尽管未达到统计学意义，但双能X线吸收法和皮褶测量均表明，体外受精儿童的全身脂肪增加。当前和早期危险因素以及父母因素（如不育原因）均无法解释体外受精儿童和对照组在通过人体测量评估的外周脂肪方面的差异。体外受精儿童和对照组之间未发现骨矿物质组成存在差异。
我们的观察结果表明，体外受精儿童的体脂组成受到干扰。对体外受精儿童进行随访，以监测其从青春期到成年期的体脂模式以及潜在的相关健康问题，具有重要意义。
