探究辅助生殖技术与围产期不良结局的关联。

Investigating the Association of Assisted Reproduction Techniques and Adverse Perinatal Outcomes.

作者信息

Potiris Anastasios, Perros Paraskevas, Drakaki Eirini, Mavrogianni Despoina, Machairiotis Nikolaos, Sfakianakis Antonios, Karampitsakos Theodoros, Vrachnis Dionysios, Antonakopoulos Nikolaos, Panagopoulos Periklis, Drakakis Peter, Stavros Sofoklis

机构信息

Third Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.

First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.

出版信息

J Clin Med. 2024 Jan 6;13(2):328. doi: 10.3390/jcm13020328.

DOI:10.3390/jcm13020328

PMID:38256462

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10816234/

Abstract

BACKGROUND

Infertility affects about 80 million individuals worldwide and 10-15% of couples at reproductive age will seek medical assistance. There is increasing evidence that pregnancies after Assisted Reproduction Techniques (ART) are associated with pre-term birth, low birthweight, congenital defects, and increased mortality rates. The aim of this review is to assess all the published literature and provide an updated review on the effect of assisted conception and perinatal and neonatal outcomes.

METHODS

Comprehensive research on Pubmed/Medline, Scopus, and Google scholar electronic databases was conducted from July 2023 up to September 2023, using the terms assisted reproductive techniques, ART, in vitro fertilization, IVF, intracytoplasmic sperm injection, ICSI, preterm birth, PTB, low birth weight, LBW, chromosomal defects, congenital defects, and hypospadias. In total, 87 full text articles were retrieved and after a careful evaluation, 31 studies were selected for data extraction.

RESULTS

Our review demonstrated a higher risk of congenital and chromosomal defects, and a higher incidence of male genital tract defects and heart defects in ART pregnancies. Regarding pre-term birth, our results were contradictory.

CONCLUSIONS

Although assisted reproduction techniques are associated with increased risks, they are safe regarding perinatal outcomes and couples should not be discouraged from utilizing them. Our results aim to alert clinicians to these specific outcomes and offer more personalized care and counseling to infertile couples and their children.

摘要

背景

不孕症影响着全球约8000万人，10%-15%的育龄夫妇会寻求医疗帮助。越来越多的证据表明，辅助生殖技术（ART）后的妊娠与早产、低出生体重、先天性缺陷及死亡率增加有关。本综述的目的是评估所有已发表的文献，并就辅助受孕对围产期和新生儿结局的影响提供最新综述。

方法

于2023年7月至2023年9月在PubMed/Medline、Scopus和谷歌学术电子数据库中进行全面检索，检索词包括辅助生殖技术、ART、体外受精、IVF、卵胞浆内单精子注射、ICSI、早产、PTB、低出生体重、LBW、染色体缺陷、先天性缺陷和尿道下裂。共检索到87篇全文文章，经过仔细评估，选择31项研究进行数据提取。