Subbiah Sujata, Sankarnarayanan S, Thomas Philip A, Nelson Jesudasan C A
Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli, Tamil Nadu, India.
Indian J Ophthalmol. 2007 Jul-Aug;55(4):283-7. doi: 10.4103/0301-4738.33041.
To correlate the findings of optical coherence tomography (OCT) evaluation of retinal nerve fiber layer (RNFL) thickness with visual field changes in glaucomatous, ocular hypertensive and normal eyes.
Thirty consecutive normal, 30 consecutive ocular hypertensive and 30 consecutive glaucomatous eyes underwent a complete ophthalmic examination, including applanation tonometry, disc evaluation, (30-2) Humphrey field analyzer white on white (W/W) perimetry and short- wavelength automated perimetry. Thickness of the RNFL around the optic disc was determined with 3.4 mm diameter-wide OCT scans. Average and segmental RNFL thickness values were compared among all groups. A correlation was sought between global indices of perimetry and RNFL thickness.
Of the 90 eyes enrolled (mean age of patients 52.32+/-10.11 years), the mean RNFL thickness was significantly less in ocular hypertensive (82.87+/-17.21 mm; P =0.008 and glaucomatous eyes (52.95+/-31.10 microm; P < 0.001), than in normals (94.26+/-12.36 microm). The RNFL was significantly thinner inferiorly in glaucomatous eyes (64.41+/-43.68 microm; P<0.001). than in normals (120.15+/-14.32 microm) and ocular hypertensives (107.87+/-25.79 microm; P<0.001). Ocular hypertensives had thinner RNFL in the nasal, inferior and temporal quadrants (P<0.001) when compared to normals. Global indices in ocular hypertensives on SWAP showed Mean Deviation (MD) of 5.32+/-4.49, Pattern Standard Deviation (PSD) 3.83+/-1.59 and Corrected Pattern Standard Deviation (CPSD) 2.84+/-1.85. The RNFL thickness could not be significantly correlated with global indices of visual fields in ocular hypertensives.
Optical coherence tomography is capable of detecting changes at the level of RNFL in ocular hypertensive eyes with normal appearance of discs and W/W perimetry fields.
将视网膜神经纤维层（RNFL）厚度的光学相干断层扫描（OCT）评估结果与青光眼、高眼压症及正常眼的视野变化进行关联。
对30例连续的正常眼、30例连续的高眼压症眼和30例连续的青光眼眼进行全面眼科检查，包括压平眼压测量、视盘评估、（30-2）Humphrey视野分析仪白色对白色（W/W）视野检查及短波长自动视野检查。使用直径3.4mm宽的OCT扫描确定视盘周围RNFL的厚度。比较所有组的平均及分段RNFL厚度值。寻找视野全局指标与RNFL厚度之间的相关性。
在纳入的90只眼中（患者平均年龄52.32±10.11岁），高眼压症眼（82.87±17.21μm；P =0.008）和青光眼眼（52.95±31.10μm；P <0.001）的平均RNFL厚度显著低于正常眼（94.26±12.36μm）。青光眼眼下半部分的RNFL显著更薄（64.41±43.68μm；P<0.001），低于正常眼（120.15±14.32μm）和高眼压症眼（107.87±25.79μm；P<0.001）。与正常眼相比，高眼压症眼在鼻侧、颞下象限和颞侧象限的RNFL更薄（P<0.001）。高眼压症眼在SWAP上的全局指标显示平均偏差（MD）为5.32±4.49，模式标准偏差（PSD）为3.83±1.59，校正模式标准偏差（CPSD）为2.84±1.85。高眼压症眼中RNFL厚度与视野全局指标无显著相关性。
光学相干断层扫描能够检测视盘外观和W/W视野检查正常的高眼压症眼中RNFL水平的变化。
