Tiryaki Demir Semra, Oba Mehmet Ersin, Erdoğan Ezgi Tuna, Odabaşı Mahmut, Dirim Ayşe Burcu, Demir Mehmet, Can Efe, Kara Orhan, Yekta Şendül Selam
Şişli Etfal Training and Research Hospital, Clinic of Ophthalmology, İstanbul, Turkey.
Kafkas University Faculty of Medicine, Department of Ophthalmology, Kars, Turkey.
Turk J Ophthalmol. 2015 Dec;45(6):229-234. doi: 10.4274/tjo.39260. Epub 2015 Dec 5.
To investigate the correlation of visual field (VF), pattern electroretinography (PERG) and Fourier domain optical coherence tomography (FD-OCT) results in patients with ocular hypertension (OHT) and early primary open-angle glaucoma (POAG).
The study included 72 eyes of 37 patients with early POAG, 76 eyes of 38 patients with OHT, and 60 eyes of 30 controls. All subjects underwent full ophthalmologic examination, VF assessment with 24-2 Humphrey standard automated perimetry (Swedish Interactive Thresholding Algorithm (SITA)-Standard), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness measurement with FD-OCT, and PERG P50 and N95 wave latency and amplitude measurements with electroretinography (Nihon Kohden).
With the exception of the nasal quadrant, all GCC parameters and RNFL results were significantly lower in the POAG group compared to the OHT and control groups. There was no statistically significant difference between the OHT and control group. PERG amplitudes were lower in the POAG and OHT groups than in the control group. Reduction in N95 amplitude was greater than that of P50 amplitude. No difference was detected in PERG latencies among groups. GCC was significantly correlated with VF and RNFL in the POAG group.
Significant thinning of the GCC and RNFL occurs in addition to VF pathologies in patients with early POAG, and these examinations should be concomitantly evaluated. During diagnostic assessment of patients with early POAG, GCC and RNFL analysis by FD-OCT are highly effective. GCC is as reliable as RNLF in the early diagnosis of glaucoma and there is a highly significant correlation between them. Dysfunction of ganglion cells in patients with OHT may be detected earlier using PERG amplitude analysis.
研究高眼压症（OHT）和早期原发性开角型青光眼（POAG）患者的视野（VF）、图形视网膜电图（PERG）和傅里叶域光学相干断层扫描（FD-OCT）结果之间的相关性。
该研究纳入了37例早期POAG患者的72只眼、38例OHT患者的76只眼以及30例对照者的60只眼。所有受试者均接受了全面的眼科检查、使用24-2 Humphrey标准自动视野计（瑞典交互式阈值算法（SITA）-标准）进行VF评估、使用FD-OCT测量视网膜神经纤维层（RNFL）和神经节细胞复合体（GCC）厚度，以及使用视网膜电图（日本光电）测量PERG的P50和N95波潜伏期及振幅。
除鼻侧象限外，POAG组的所有GCC参数和RNFL结果均显著低于OHT组和对照组。OHT组和对照组之间无统计学显著差异。POAG组和OHT组的PERG振幅低于对照组。N95振幅的降低大于P50振幅。各组之间PERG潜伏期未检测到差异。POAG组中GCC与VF和RNFL显著相关。
早期POAG患者除了存在VF病变外，还出现GCC和RNFL的显著变薄，这些检查应同时进行评估。在早期POAG患者的诊断评估中，FD-OCT对GCC和RNFL的分析非常有效。GCC在青光眼的早期诊断中与RNLF一样可靠，且它们之间存在高度显著的相关性。使用PERG振幅分析可能更早地检测出OHT患者的神经节细胞功能障碍。
