Husby H, Holm N V, Gernow A, Thomsen S G, Kock K, Gürtler H
Institute of Medical Genetics, Copenhagen University, Denmark.
Acta Genet Med Gemellol (Roma). 1991;40(2):147-52. doi: 10.1017/s0001566000002579.
The usual assumption that monochorionic twins are monozygotic has recently been questioned, based on blood group discordance in 3 of 12 monochorionic pairs. Therefore, this study evaluates the validity of zygosity diagnosis based on examination of placental membranes, and at the same time evaluates Weinberg's differential rule in a Danish consecutive twin series. All twin pairs, 265 like-sexed and 87 unlike-sexed pairs, born at Odense University Hospital, Denmark, from 1 January 1980 through 31 August 1988, were ascertained. In 229 like-sexed pairs, zygosity was determined by serological methods, and in 190 of these, the fetal membranes could be reliably classified. Fifty-nine monochorionic twin pairs were identified and none of those pairs were discordant for any genetic markers. Therefore, we conclude that monochorionic twins can be considered monozygotic. The distribution of monozygotic and dizygotic pairs was in accordance with Weinberg's rule.
基于12对单绒毛膜双胎中有3对血型不一致，通常认为单绒毛膜双胎是单卵双胎这一假设最近受到了质疑。因此，本研究评估了基于胎盘膜检查的合子性诊断的有效性，同时在丹麦连续双胎系列中评估了温伯格差异法则。确定了1980年1月1日至1988年8月31日在丹麦欧登塞大学医院出生的所有双胎对，其中265对同性双胎和87对异性双胎。在229对同性双胎中，通过血清学方法确定合子性，其中190对的胎膜可可靠分类。鉴定出59对单绒毛膜双胎，这些双胎对中没有任何一对在任何遗传标记上不一致。因此，我们得出结论，单绒毛膜双胎可被认为是单卵双胎。单卵双胎和双卵双胎对的分布符合温伯格法则。
