Poiată Antonia, Tuchiluş Cristina, Bădicuţ Ioana, Buiuc D
Disciplina de Microbiologie, Facultatea de Farmacie, Universitatea de Medicină Si Farmacie "Gr. T. Popa", Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2007 Jan-Mar;111(1):276-9.
Cefpirome is a fourth-generation cephalosporin with an expanded spectrum against both Gram-negative and Gram-positive bacteria. The objective of this study was to evaluate the in vitro activity of cefpirome against staphylococci, clinical isolates. For comparison oxacillin was also tested.
A total 434 isolates (coagulase-positive staphylococci, n = 268 and coagulase-negative staphylococci, n = 166) were tested. Susceptibility testing was performed using the Mueller-Hinton agar dilution method.
Cefpirome inhibited the majority of strains at 0.5-8 mg/l. Cefpirome had excellent activity against coagulase-negative staphylococci with 91.6% susceptibility. Except the coagulase-positive staphylococci, of the 268 isolates, 81.3% were cefpirome sensitive. Concerning oxacillin, 35.1% of coagulase-positive staphylococci isolates were resistant, comparative with 26.5% of the coagulase-negative staphylococci. A cross-resistance analysis showed the association of resistance between cefpirome and oxacillin.
Against staphylococci, cefpirome had the best activity when compared with the oxacillin.
头孢匹罗是一种第四代头孢菌素，对革兰氏阴性菌和革兰氏阳性菌均具有扩大的抗菌谱。本研究的目的是评估头孢匹罗对葡萄球菌临床分离株的体外活性。为作比较，还对苯唑西林进行了测试。
共测试了434株分离株（凝固酶阳性葡萄球菌，n = 268；凝固酶阴性葡萄球菌，n = 166）。采用 Mueller-Hinton 琼脂稀释法进行药敏试验。
头孢匹罗在0.5 - 8mg/l时可抑制大多数菌株。头孢匹罗对凝固酶阴性葡萄球菌具有优异活性，敏感性为91.6%。在268株凝固酶阳性葡萄球菌分离株中，除凝固酶阳性葡萄球菌外，81.3%对头孢匹罗敏感。关于苯唑西林，35.1%的凝固酶阳性葡萄球菌分离株耐药，而凝固酶阴性葡萄球菌的这一比例为26.5%。交叉耐药性分析显示头孢匹罗与苯唑西林之间存在耐药关联。
与苯唑西林相比，头孢匹罗对葡萄球菌具有最佳活性。
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