[β-淀粉样肽影响陆生蜗牛的行为可塑性]

[Beta-amyloid peptide influences behavioral plasticity in terrestrial snail].

作者信息

Korshunova T A, Samarova E I, Bravarenko N I, Balaban P N

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 2007 Mar-Apr;57(2):229-36.

Abstract

Influence of neurotoxic fragment of beta-amyloid peptide (25-35) on Helix lucorum behavioral plasticity (sensitization and food-aversion learning) was investigated. After beta-amyloid peptide (25-35) injection a significant reduction of behavioral long-term sensitization was observed. It was found, that beta-amyloid peptide (25-35) may interfere with associative learning and memory. Our results clearly demonstrate that beta-amyloid peptide (25-35) may play a significant role in behavioral plasticity by chronically eliminating certain underlying forms of synaptic plasticity.

摘要

研究了β-淀粉样肽（25-35）的神经毒性片段对中华大扁锹行为可塑性（敏化和食物厌恶学习）的影响。注射β-淀粉样肽（25-35）后，观察到行为长期敏化显著降低。研究发现，β-淀粉样肽（25-35）可能干扰联想学习和记忆。我们的结果清楚地表明，β-淀粉样肽（25-35）可能通过长期消除某些潜在形式的突触可塑性在行为可塑性中发挥重要作用。