Pankova N B, Krupina N A, Orlova I N, Khlebnikova N N, Kryzhanovskiĭ G N
Zh Vyssh Nerv Deiat Im I P Pavlova. 2007 Mar-Apr;57(2):243-54.
Depressive state was produced in Wistar rats by repeated intraperitoneal administration of proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) inducing death of brain dopaminergic neurons. Weight loss and increase in REM-sleep rate during diurnal sleep were considered to be signs of the development of an experimental depressive state. During the development of the depressive state of rats, the MPTP-induced reorganization of the spectral power of electrical activity was observed in the terminal fields of the nigrostriatal, mesocortical, and mesolimbic dopaminergic systems, amygdala, and hippocampus. The most pronounced changes were revealed in the terminal field of the nigrostriatal system and hippocampus. The reorganization of the spectral power in the thetal and theta2 bands in the hippocampus and dopaminergic structures suggests the involvement of the hippocampus in producing changes in the emotional state during development of the MPTP-induced depressive syndrome.
通过反复腹腔注射神经毒素原1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导脑多巴胺能神经元死亡，从而在Wistar大鼠中产生抑郁状态。体重减轻和日间睡眠期间快速眼动睡眠率增加被认为是实验性抑郁状态发展的迹象。在大鼠抑郁状态发展过程中，在黑质纹状体、中皮质和中边缘多巴胺能系统、杏仁核和海马体的终末区域观察到MPTP诱导的电活动频谱功率重组。在黑质纹状体系统和海马体的终末区域发现了最明显的变化。海马体和多巴胺能结构中θ波和θ2波频段的频谱功率重组表明，在MPTP诱导的抑郁综合征发展过程中，海马体参与了情绪状态变化的产生。
