Gugutsidze D A, Nerobkova L N, Boronina T A
Biull Eksp Biol Med. 1989 Aug;108(8):206-9.
The structure of the sleep-wakefulness cycle on the white rats with experimental parkinsonian syndrome was investigated, which was induced by administration of MPTP and oxotremorine. The EEG was recorded during 6 hours. The recordings were made 1.5 hours after the administration of the drugs. It was established that MPTP and oxotremorine broke the structure of the sleep-wakefulness cycle almost with complete reduction of paradoxal sleep and the decrease of SWS. The number of sleep spindles was reduced and changed the characteristics of the hippocampal theta rhythms. MPTP induces weakness of the phasic compound and strengthens the tonic compound.
研究了用1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）和氧化震颤素诱导实验性帕金森综合征的大白鼠睡眠-觉醒周期结构。在6小时内记录脑电图。记录在给药后1.5小时进行。结果表明，MPTP和氧化震颤素破坏了睡眠-觉醒周期结构，几乎完全减少了异相睡眠并降低了慢波睡眠。睡眠纺锤波数量减少，海马θ节律特征改变。MPTP导致相位复合波减弱，增强了强直复合波。
