Tejada S, Rial R V, Coenen A M L, Gamundi A, Esteban S
Laboratori de Neurofisiologia, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, IUNICS, Palma de Mallorca, Spain.
Eur J Neurosci. 2007 Jul;26(1):199-206. doi: 10.1111/j.1460-9568.2007.05647.x. Epub 2007 Jun 26.
It has been suggested that theta rhythm gates the flow of information between the hippocampus and cortex during memory processes. The cholinergic system plays an important role in regulating vigilance states and in generating theta rhythm. This study aims to analyse the effects of the muscarinic agonist pilocarpine (120 and 360 microg, i.c.v.) on hippocampal and frontal cortical theta rhythm during several vigilance states in rats. Pilocarpine injection increased the duration and number of episodes with theta activity, particularly when theta rhythm appeared during waking states in the cortex and hippocampus simultaneously. It seems that the effects of pilocarpine are related to the appearance of cortical theta activity in waking states, and suggest that pilocarpine could modify the transference rate of information from the hippocampus to cortex in rats during wakefulness states, in relation to the postulated effect of cholinergic system modulating memory consolidation.
有人提出，在记忆过程中，θ节律控制着海马体和皮层之间的信息流。胆碱能系统在调节警觉状态和产生θ节律方面起着重要作用。本研究旨在分析毒蕈碱激动剂毛果芸香碱（120和360微克，脑室内注射）对大鼠几种警觉状态下海马体和额叶皮层θ节律的影响。注射毛果芸香碱增加了θ活动的持续时间和发作次数，特别是当θ节律同时出现在皮层和海马体的清醒状态时。毛果芸香碱的作用似乎与清醒状态下皮层θ活动的出现有关，这表明毛果芸香碱可能会改变大鼠清醒状态下从海马体到皮层的信息传递速率，这与胆碱能系统调节记忆巩固的假定作用有关。
