Yamamoto J
Pharmacological Research Laboratory, Taiho Pharmaceutical, Tokushima, Japan.
Eur J Pharmacol. 1998 Oct 23;359(2-3):133-7. doi: 10.1016/s0014-2999(98)00685-2.
The effects of three cholinergic agents on hippocampal theta waves were investigated by analyzing electroencephalographic power spectra in freely moving rabbits. In the hippocampal spectra, nicotine (a nicotinic receptor agonist, 0.03 mg/kg) increased the theta wave frequency, but caused no change in its power. Pilocarpine (a muscarinic receptor agonist, 0.3 and 1.0 mg/kg) and tetrahydroaminoacridine (a cholinesterase inhibitor, 3.0 mg/kg) increased the power and deceased the frequency. These results suggest that the activating effect of nicotinic receptor agonists on the hippocampus may be different from that of muscarinic receptor agonists or cholinesterase inhibitors.
通过分析自由活动兔子的脑电图功率谱，研究了三种胆碱能药物对海马θ波的影响。在海马谱中，尼古丁（一种烟碱受体激动剂，0.03mg/kg）增加了θ波频率，但对其功率无影响。毛果芸香碱（一种毒蕈碱受体激动剂，0.3和1.0mg/kg）和他克林（一种胆碱酯酶抑制剂，3.0mg/kg）增加了功率并降低了频率。这些结果表明，烟碱受体激动剂对海马的激活作用可能与毒蕈碱受体激动剂或胆碱酯酶抑制剂不同。
