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[小龙虾神经肌肉传递的短期和长期抑制]

[Short and long term depression of neuromuscular transmission in crayfish].

作者信息

Czternasty G, Bruner J

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 Nov 17;281(20):1493-6.

PMID:175970
Abstract

Following single excitation of the abdominal giant motoneuron of crayfish, an important depression of neuro-muscular transmission is observed for about 15 mn. The time course of recovery is not modified even after low frequency (1/30 Hz) repetitive stimulation. Recovery curves obtained for different Mg++ concentration in physiological solutions show two phases of depression: short-term depression which is largely reduced in high Mg++ concentrations - thus probably depending on transmitter depletion in motoneuron terminals - long-term depression which is not modified by changing Mg++ concentration and seems to be independent of depletion.

摘要

对小龙虾腹部巨型运动神经元进行单次刺激后,可观察到神经肌肉传递出现约15分钟的显著抑制。即使在低频(1/30赫兹)重复刺激后,恢复的时间进程也未改变。在生理溶液中针对不同镁离子浓度获得的恢复曲线显示出两个抑制阶段:短期抑制在高镁离子浓度下大幅降低——因此可能取决于运动神经元终末中的递质耗竭——长期抑制不受镁离子浓度变化的影响,似乎与递质耗竭无关。

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