Holman B L
Circulation. 1976 Mar;53(3 Suppl):I112-9.
Radionuclide techniques that assess regional myocardial perfusion and detect acute myocardial infarction promise to provide critical information in the detection and evaluation of coronary artery disease and in the assessment of therapies aimed at limiting the degree of ischemia and the extent of tissue necrosis. Radioindicators such as 99mTc-tetracycline and 99mTc-pyrophosphate which are sequestered by acutely infarcted myocardium provide a direct method to detect an infarct and to determine its size. Regional alterations in myocardial perfusion can be assessed by myocardial scintigraphy performed after the injection of radiopotassium or one of its analogues with the patient either at rest or at exercise. A somewhat more accurate evaluation of the extent of altered perfusion can be obtained after the intracoronary injection of macro-aggregated particles. A quantitative index of altered perfusion can be obtained after the intracoronary injection of an inert gas such as 133Xe.
评估局部心肌灌注和检测急性心肌梗死的放射性核素技术有望在冠状动脉疾病的检测和评估以及旨在限制缺血程度和组织坏死范围的治疗评估中提供关键信息。诸如99mTc - 四环素和99mTc - 焦磷酸盐等放射性指示剂可被急性梗死心肌摄取，提供了一种直接检测梗死并确定其大小的方法。在注射放射性钾或其类似物后，对静息或运动状态下的患者进行心肌闪烁扫描，可评估心肌灌注的局部改变。冠状动脉内注射大颗粒聚合体后，能对灌注改变的程度进行更准确的评估。冠状动脉内注射诸如133Xe等惰性气体后，可获得灌注改变的定量指标。
