Holman B L, Jones A G, Davis M A, Askenazi J, Maroko P R
J Nucl Med. 1976 Jun;17(6):508-11.
The feasibility of double-labeling of acute myocardial infarcts with 113mIn-EDTMP [ethylenediaminetetra(methylene phosphonic acid)] and 99mTc-EDTMP was evaluated. The in vitro distributions of these tracers in acute myocardial infarcts in dogs and their selectivities for infarcted versus noninfarcted myocardium were compared. Both tracers concentrated in acutely infarcted myocardium, and there was excellent correlation between their uptakes (r = 0.88). They also provided complete separation between infarcted and uninfarcted tissue, as checked by histology. Accordingly, these agents show promise for the multiple-labeling of acute myocardial infarcts in experiments to determine the natural course of myocardial infarction and the efficacy of therapy aimed at limiting infarct size. In addition, 113mIn-EDTMP may be useful for serial scintigraphy during the early phase of acute myocardial infarction when the damage may be, at least to some extent, reversible.
评估了用¹¹³m铟-乙二胺四亚甲基膦酸（¹¹³mIn-EDTMP）和锝-99m-乙二胺四亚甲基膦酸（⁹⁹mTc-EDTMP）对急性心肌梗死进行双重标记的可行性。比较了这些示踪剂在犬急性心肌梗死中的体外分布及其对梗死心肌与非梗死心肌的选择性。两种示踪剂均在急性梗死心肌中浓聚，它们的摄取之间存在极好的相关性（r = 0.88）。经组织学检查，它们还能使梗死组织与未梗死组织完全区分开来。因此，在确定心肌梗死自然病程及旨在限制梗死面积的治疗效果的实验中，这些药物有望用于急性心肌梗死的多重标记。此外，¹¹³mIn-EDTMP在急性心肌梗死早期阶段进行系列闪烁扫描时可能有用，此时损伤至少在一定程度上是可逆的。
