脊髓强啡肽增加促成大鼠慢性尼古丁诱导的机械性超敏反应。
Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat.
作者信息
Lough Chris, Young Tracey, Parker Renee, Wittenauer Shannon, Vincler Michelle
机构信息
Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA.
出版信息
Neurosci Lett. 2007 Jul 5;422(1):54-8. doi: 10.1016/j.neulet.2007.06.002. Epub 2007 Jun 8.
Abstract
Chronic nicotine administration has been shown previously to produce mechanical hypersensitivity in the rat although the mechanism of this effect is unknown. Rats treated with chronic systemic nicotine 3.6 or 8.6 mg/(kg day) for 14-21 days displayed mechanical hypersensitivity coincident with an increase of prodynorphin immunoreactivity and dynorphin content within the spinal cord. The administration of dynorphin antiserum intrathecally significantly attenuated chronic nicotine-induced mechanical hypersensitivity. Our results suggest that chronic nicotine administration produces an increase in spinal dynorphin content and release that contributes to mechanical hypersensitivity.
摘要
先前的研究表明，长期给予尼古丁会使大鼠产生机械性超敏反应，但其作用机制尚不清楚。用3.6或8.6毫克/（千克·天）的慢性全身性尼古丁处理大鼠14 - 21天，会出现机械性超敏反应，同时脊髓内前强啡肽免疫反应性和强啡肽含量增加。鞘内注射强啡肽抗血清可显著减轻慢性尼古丁诱导的机械性超敏反应。我们的结果表明，长期给予尼古丁会导致脊髓强啡肽含量和释放增加，从而导致机械性超敏反应。
相似文献
1
Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat.脊髓强啡肽增加促成大鼠慢性尼古丁诱导的机械性超敏反应。
Neurosci Lett. 2007 Jul 5;422(1):54-8. doi: 10.1016/j.neulet.2007.06.002. Epub 2007 Jun 8.
2
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.脊髓甲硫氨酸脑啡肽参与尼古丁诱导的小鼠抗伤害感受作用。
Brain Res. 2008 Jan 16;1189:70-7. doi: 10.1016/j.brainres.2007.10.086. Epub 2007 Nov 7.
3
Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia.脊髓强啡肽和缓激肽受体维持炎性痛觉过敏。
J Pain. 2008 Dec;9(12):1096-105. doi: 10.1016/j.jpain.2008.06.005. Epub 2008 Oct 31.
4
Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum.急性尼古丁会改变纹状体中强啡肽和前强啡肽的信使核糖核酸。
Psychopharmacology (Berl). 2009 Jan;201(4):507-16. doi: 10.1007/s00213-008-1315-4. Epub 2008 Sep 21.
5
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers.持续暴露于吗啡会诱导脊髓中强啡肽依赖性增强初级传入纤维兴奋性递质的释放。
J Neurosci. 2002 Aug 1;22(15):6747-55. doi: 10.1523/JNEUROSCI.22-15-06747.2002.
6
Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats.大鼠切口手术后脊髓强啡肽表达增加，但不驱动小胶质细胞前列腺素生成或机械性超敏反应。
Pain. 2006 Nov;125(1-2):43-52. doi: 10.1016/j.pain.2006.04.027. Epub 2006 Jun 5.
7
Impact of chronic nicotine on the development and maintenance of neuropathic hypersensitivity in the rat.慢性尼古丁对大鼠神经性超敏反应的发生及维持的影响
Psychopharmacology (Berl). 2006 Oct;188(2):152-61. doi: 10.1007/s00213-006-0481-5. Epub 2006 Aug 17.
8
Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models.布拉他丁A刺激脊髓小胶质细胞强啡肽A的表达，从而在多种大鼠疼痛模型中产生抗超敏反应。
J Neuroinflammation. 2016 Aug 30;13(1):214. doi: 10.1186/s12974-016-0696-2.
9
Pronociceptive actions of dynorphin maintain chronic neuropathic pain.强啡肽的促伤害感受作用维持慢性神经性疼痛。
J Neurosci. 2001 Mar 1;21(5):1779-86. doi: 10.1523/JNEUROSCI.21-05-01779.2001.
10
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation.强啡肽在未受伤动物中的促伤害感受作用：N-乙基马来酰亚胺诱导的伤害感受行为通过抑制强啡肽降解介导。
Pain. 2005 Feb;113(3):301-309. doi: 10.1016/j.pain.2004.11.004.
引用本文的文献
1
Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain.小胶质细胞在尼古丁引起的疼痛中维持扣带回皮质神经元的过度兴奋。
J Neuroinflammation. 2023 Mar 21;20(1):81. doi: 10.1186/s12974-023-02767-0.
2
Dynorphin participates in interaction between depression and non-erosive reflux disease.脑啡肽参与抑郁和非糜烂性反流病的相互作用。
Esophagus. 2023 Jan;20(1):158-169. doi: 10.1007/s10388-022-00955-0. Epub 2022 Oct 16.
3
Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking.动物模型暴露于尼古丁：与二手烟、电子烟使用和强迫吸烟的相关性。
Front Psychiatry. 2013 Jun 4;4:41. doi: 10.3389/fpsyt.2013.00041. eCollection 2013.
4
Nicotine: alcohol reward interactions.尼古丁：酒精奖赏相互作用。
Neurochem Res. 2010 Aug;35(8):1248-58. doi: 10.1007/s11064-010-0181-8. Epub 2010 May 25.
5
Pronociceptive actions of dynorphin via bradykinin receptors.强啡肽通过缓激肽受体产生的促伤害感受作用。
Neurosci Lett. 2008 Jun 6;437(3):175-9. doi: 10.1016/j.neulet.2008.03.088. Epub 2008 Apr 8.
本文引用的文献
1
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.表达脊髓NK-1受体的神经元通过下行通路的激活介导阿片类药物诱导的痛觉过敏和抗伤害感受性耐受。
Pain. 2007 May;129(1-2):35-45. doi: 10.1016/j.pain.2006.09.033. Epub 2006 Nov 22.
2
Dynorphin A activates bradykinin receptors to maintain neuropathic pain.强啡肽A激活缓激肽受体以维持神经性疼痛。
Nat Neurosci. 2006 Dec;9(12):1534-40. doi: 10.1038/nn1804. Epub 2006 Nov 19.
3
Impact of chronic nicotine on the development and maintenance of neuropathic hypersensitivity in the rat.慢性尼古丁对大鼠神经性超敏反应的发生及维持的影响
Psychopharmacology (Berl). 2006 Oct;188(2):152-61. doi: 10.1007/s00213-006-0481-5. Epub 2006 Aug 17.
4
Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats.大鼠切口手术后脊髓强啡肽表达增加，但不驱动小胶质细胞前列腺素生成或机械性超敏反应。
Pain. 2006 Nov;125(1-2):43-52. doi: 10.1016/j.pain.2006.04.027. Epub 2006 Jun 5.
5
Morphine hyperalgesia in mice is unrelated to opioid activity, analgesia, or tolerance: evidence for multiple diverse hyperalgesic systems.小鼠中的吗啡痛觉过敏与阿片类药物活性、镇痛作用或耐受性无关：多种不同痛觉过敏系统的证据
Brain Res. 2006 Jan 27;1070(1):35-44. doi: 10.1016/j.brainres.2005.11.054. Epub 2006 Jan 10.
6
Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery.持续给予阿片类药物引起的阿片受体介导的痛觉过敏和抗伤害感受性耐受。
Neurosci Lett. 2006 Mar 20;396(1):44-9. doi: 10.1016/j.neulet.2005.11.009. Epub 2005 Dec 15.
7
Cigarette smoking, stress-induced analgesia and pain perception in men and women.男性和女性的吸烟、应激诱导镇痛与疼痛感知
Pain. 2005 Apr;114(3):372-385. doi: 10.1016/j.pain.2004.12.035.
8
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.离子型和代谢型受体、蛋白激酶A、蛋白激酶C以及Src激酶，在背根神经节神经元中，参与了C纤维诱导的细胞外信号调节激酶（ERK）激活以及环磷酸腺苷反应元件结合蛋白（CREB）磷酸化过程，从而导致中枢敏化。
J Neurosci. 2004 Sep 22;24(38):8310-21. doi: 10.1523/JNEUROSCI.2396-04.2004.
9
Antinociception induced by chronic exposure of rats to cigarette smoke.大鼠长期暴露于香烟烟雾所诱导的抗伤害感受作用。
Neurosci Lett. 2004 Aug 5;366(1):86-91. doi: 10.1016/j.neulet.2004.05.020.
10
Neuropathic pain: the paradox of dynorphin.神经性疼痛：强啡肽的矛盾之处。
Mol Interv. 2001 Aug;1(3):160-7.
Zotero 插件