Giovannini Marcello, Agostoni Carlo, Riva Enrica, Salvini Filippo, Ruscitto Antonia, Zuccotti Gian Vincenzo, Radaelli Giovanni
Department of Pediatrics, San Paolo Hospital, University of Milan, Via A di Rudinì 8, I-20142 Milan, Italy.
Pediatr Res. 2007 Aug;62(2):215-20. doi: 10.1203/PDR.0b013e3180a76d94.
To examine whether long-term consumption of fermented milk containing a specific Lactobacillus casei may improve the health status of preschool children suffering from allergic asthma and/or rhinitis a randomized, prospective, double blind, controlled trial was conducted in 187 children 2-5 y of age. The children received for 12 mo either fermented milk (100 mL) containing Lactobacillus casei (10(8) cfu/mL) or placebo. The time free from and the number of episodes of asthma/rhinitis after starting intervention were the outcome measures. The number of fever or diarrhea episodes and the change in serum immunoglobulin were further assessed. No statistical difference between intervention and control group occurred in asthmatic children. In children with rhinitis, the annual number of rhinitis episodes was lower in the intervention group, mean difference (95% CI), -1.6 (-3.15 to -0.05); the mean duration of an episode of diarrhea was lower in the intervention group, mean difference -0.81 (-1.52 to -0.10) days. While long-term consumption of fermented milk containing Lactobacillus casei may improve the health status of children with allergic rhinitis no effect was found in asthmatic children.
为研究长期食用含有特定干酪乳杆菌的发酵乳是否可改善患有过敏性哮喘和/或鼻炎的学龄前儿童的健康状况，对187名2至5岁的儿童进行了一项随机、前瞻性、双盲对照试验。这些儿童接受了为期12个月的含有干酪乳杆菌（10⁸ cfu/mL）的发酵乳（100 mL）或安慰剂。干预开始后无哮喘/鼻炎发作的时间和发作次数为观察指标。进一步评估发热或腹泻发作次数以及血清免疫球蛋白的变化。干预组和对照组的哮喘儿童之间未出现统计学差异。在患有鼻炎的儿童中，干预组的鼻炎年发作次数较低，平均差值（95% CI）为-1.6（-3.15至-0.05）；干预组腹泻发作的平均持续时间较短，平均差值为-0.81（-1.52至-0.10）天。虽然长期食用含有干酪乳杆菌的发酵乳可能改善过敏性鼻炎儿童的健康状况，但在哮喘儿童中未发现效果。
