Dong Z, Atherton S S
Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Augusta, Georgia 30912, USA.
Kidney Int. 2007 Jul;72(1):5-7. doi: 10.1038/sj.ki.5002320.
A robust inflammatory response involving tumor necrosis factor-alpha (TNF-alpha) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-alpha. Blockade of TNF-alpha attenuates inflammation and associated kidney injury.
顺铂肾毒性过程中会诱导出一种涉及肿瘤坏死因子-α（TNF-α）的强烈炎症反应。里夫斯及其同事利用嵌合模型，现已证明肾实质细胞而非浸润性免疫细胞是TNF-α的主要产生者。阻断TNF-α可减轻炎症及相关肾损伤。
